SynthesisJournal of occupational health2021
Sedentary work and breast cancer risk: A systematic review and meta-analysis.
Synthesis in Journal of occupational health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A systematic review and exploration of clinical application of liver depression syndrome in breast cancer.Frontiers in oncology · 2025Pooled it
- Risk factors for breast cancer: an umbrella review of observational cohort studies and causal relationship analysis.Frontiers in oncology · 2025Pooled it
- Pooled it
- The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies.Frontiers in oncology · 2022Pooled it
- Sedentary work and breast cancer risk: A systematic review and meta-analysis.Journal of occupational health · 2021Pooled it
- The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy.Cancer medicine · 2022Trial
- Association Between Physical Activity, Sedentary Behavior and Breast Cancer Risk Among Moroccan Women: A Multicenter Case-Control Study.Epidemiologia (Basel, Switzerland) · 2026Article
- Occupation and Female Breast Cancer Mortality in South Africa: A Case-Control Study.International journal of environmental research and public health · 2025Article
- Sedentary Time and Breast Cancer Risk in the Sister Study Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Association of lifestyle factors with breast cancer incidence: An overview of systematic reviews.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Association between daily sitting time and breast cancer among obese women: a nationwide population-based study.BMC women's health · 2025Article
- Is work burden associated with postmenopausal breast cancer? A population-based 25-year follow-up.Archives of gynecology and obstetrics · 2025Article
- Synchronous or metachronous breast and colorectal cancers in younger-than-average-age patients: a case series.The oncologist · 2024Article
- Physical Activity, Sedentary Time, and Psychosocial Functioning among Adults with Cancer: A Scoping Review.International journal of environmental research and public health · 2024Article
- Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.Cancer science · 2024Article
- Epidemiological breast cancer prediction by country: A novel machine learning approach.PloS one · 2024Article
- Article
- Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study.BMC cancer · 2023Article
- Is physical inactivity and sedentary behavior associated with tumor stage in breast cancer patients? A cross-sectional study of Brazilian women.Einstein (Sao Paulo, Brazil) · 2023Article
- Breast Cancer Incidence among Female Workers by Different Occupations and Industries: A Longitudinal Population-Based Matched Case-Control Study in Taiwan.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review and meta-analysis aimed to assess sedentary work's contribution to breast cancer risk quantitatively using thorough research articles.
methodsWe performed a meta-analysis using a registered protocol in PROSPERO (registration number: CRD42020204629). Literature from PubMed, Embase, and Cochrane involving sedentary work and breast cancer risk was reviewed. We calculated the overall pooled risk ratios (RRs) and 95% CI with a random-effect model from the included studies. Furthermore, we performed stratified analyses by characteristics of studies.
resultsThirty-one studies (13 cohort studies and 18 case-control studies) were included in the analysis. The overall effect of the pooled analysis was an RR of 1.16 (95% CI 1.08-1.23). The results were 1.20 (95% CI 1.10-1.30) and 1.12 (95% CI 1.02-1.23) for cohort and case-control studies. The effect of sedentary work did not seem to be consistently attenuated by controlling body mass index, menopausal status, or experience of hormone replacement therapy.
conclusionThe results from this meta-analysis suggest that sedentary behavior within the occupational domain was associated with a 15.5% increased risk of breast cancer. It is essential to reduce the sedentary time spent at work and to secure time for leisure-time physical activity among sedentary workers as a primary preventive measure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.