Trial reportCancer2021
A randomized trial of exercise and diet on health-related quality of life in survivors of breast cancer with overweight or obesity.
Trial report in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Do Combined Resistance and Aerobic Exercise Programs Cause an Interference Effect in Women with Breast Cancer? A Systematic Review and Network Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The effects of combined aerobic and resistance exercise on metabolic blood biomarkers and quality of life in patients with breast cancer: a systematic review meta-analysis.Frontiers in oncology · 2026Pooled it
- A meta-analysis of healthy lifestyle interventions addressing quality of life of cancer survivors in the post treatment phase.Journal of cancer survivorship : research and practice · 2025Pooled it
- Combined Effects of Physical Activity and Diet on Cancer Patients: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Pooled it
- Comparative effects of different types of exercise on health-related quality of life during and after active cancer treatment: A systematic review and network meta-analysis.Journal of sport and health science · 2023Pooled it
- Exercise interventions on body composition and quality of life of overweight/obese breast cancer survivors: a meta-analysis.BMC women's health · 2023Pooled it
- Effect of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Fat Loss and Cardiorespiratory Fitness in the Young and Middle-Aged a Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Effects of Combined Interventions of Exercise and Diet or Exercise and Supplementation on Breast Cancer Patients: A Systematic Review.Nutrients · 2023Pooled it
- The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors.Breast cancer research and treatment · 2023Trial
- The effects of a clinic-based weight loss program on health-related quality of life and weight maintenance in cancer survivors: A randomized controlled trial.Psycho-oncology · 2022Trial
- Current Evidence on the Impact of Diet, Food, and Supplement Intake on Breast Cancer Health Outcomes in Patients Undergoing Endocrine Therapy.Nutrients · 2025Review
- Comprehensive Breast Cancer-Related Lymphedema Management Programs Addressing both Psychosocial and Physical Needs: A Scoping Review.The open journal of occupational therapy · 2025Article
- Narrative review of lifestyle interventions in breast cancer survivors: current evidence and future directions.JNCI cancer spectrum · 2024Review
- Influence of Obesity and Sociodemographic Features on the Physical Fitness of Breast Cancer Survivors.Geriatrics (Basel, Switzerland) · 2024Article
- Survivors Overcoming and Achieving Resiliency (SOAR): Mindful Eating Practice for Breast Cancer Survivors in a Virtual Teaching Kitchen.Nutrients · 2023Article
- Global Scientific Trends on Healthy Eating from 2002 to 2021: A Bibliometric and Visualized Analysis.Nutrients · 2023Review
- Adherence to Mediterranean Diet and Nutritional Status in Women with Breast Cancer: What Is Their Impact on Disease Progression and Recurrence-Free Patients' Survival?Current oncology (Toronto, Ont.) · 2022Article
- Clinical and sociodemographic characteristics associated with health-related quality of life among older breast cancer survivors.Women's health (London, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundObesity is a chronic, relapsing, and progressive disease; it is associated with poor health-related quality of life (HRQOL) in survivors of breast cancer.
methodsIn this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to 1 of 4 treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. HRQOL end points were measured at baseline and at week 52 using the 36-Item Medical Outcomes Survey-Short Form (SF-36). Repeated measures analysis of covariance quantified the estimated treatment difference (ETD).
resultsAt baseline, participants had a mean (SD) age of 59.4 years (8.7), body mass index of 34.0 kg/m
conclusionIn survivors of breast cancer with overweight or obesity, exercise plus diet improved select HRQOL end points at week 52.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.