ArticleChemical senses2021
Cyclophosphamide-Induced Inflammation of Taste Buds and Cytoprotection by Amifostine.
Article in Chemical senses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Oral manifestations and dental management in patients undergoing CAR-T cell therapy: a retrospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- The protective effect of baicalin against cyclophosphamide-induced testicular damage in rats.Open veterinary journal · 2025Article
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Cyclophosphamide induces the loss of taste bud innervation in mice.Chemical senses · 2024Article
- Cisplatin attenuates taste cell homeostasis and induces inflammatory activation in the circumvallate papilla.Theranostics · 2023Article
- Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy-A Narrative Review.Nutrients · 2023Review
- Impact of Co-Administration of N-Acetylcysteine and Vitamin E on Cyclophosphamide-Induced Ovarian Toxicity in Female Rats.Journal of toxicology · 2022Article
- Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration?Chemical senses · 2022Review
- Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study.Frontiers in oral health · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Taste buds in the oral cavity have a complex immune system regulating normal functions and inflammatory reactions. Cyclophosphamide (CYP), a chemotherapy drug, has wide-ranging disruptive effects on the taste system including loss of taste function, taste sensory cells, and capacity for taste cell renewal. In bladder epithelium, CYP also induces inflammation. To determine if CYP induces inflammation in taste buds, we used immunohistochemistry to examine tumor necrosis factor alpha (TNF-α) (a proinflammatory cytokine) expression over a 72-hour period. Expression of TNF-α increased in a subset of PLCβ2 labeled (Type II) cells, but not SNAP-25 labeled (Type III) cells, between 8 and 24 h postinjection and declined slowly thereafter. This inflammatory response may play an important role in the disruptive effects of CYP on the taste system. Further, pretreatment with amifostine, a sulfhydryl drug known to protect normal tissues during chemo- or radiation therapy, reduced the amount of CYP-induced TNF-α expression in taste buds, suggesting this drug is capable of protecting normal cells of the taste system from adverse effects of CYP. Amifostine, used as a pretreatment to CYP and possibly other chemotherapy drugs, may offer clinical support for preventing negative side effects of chemotherapy on the taste system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.