Evidence map›Paper›PMID 34161280›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Localized chondro-ossification underlies joint dysfunction and motor deficits in the

Joohyun Lim, Caressa Lietman, Matthew W Grol, Alexis Castellon, Brian Dawson, Mary Adeyeye, Jyoti Rai, MaryAnn Weis, Douglas R Keene, Ronen Schweitzer and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  9. Review
  10. Review
  11. Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism.Frontiers in cell and developmental biology · 2023
    Review
  12. An Update on Animal Models of Osteogenesis Imperfecta.Calcified tissue international · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Joohyun LimDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-9670-806X
Caressa LietmanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-3863-2751
Matthew W GrolDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-6514-9066
Alexis CastellonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Brian DawsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Mary AdeyeyeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-4900-2237
Jyoti RaiDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195.
MaryAnn WeisDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195.
Douglas R KeeneResearch Division, Shriners Hospital for Children, Portland, OR 97239.
Ronen SchweitzerResearch Division, Shriners Hospital for Children, Portland, OR 97239.ORCID 0000-0002-7425-5028
Dongsu ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
David R EyreDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195.ORCID 0000-0003-2605-8545
Deborah KrakowDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095.ORCID 0000-0001-9906-4968
Brendan H LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; blee@bcm.edu.
Baylor College of Medicine · USUniversity of Washington · USShriners Hospitals for Children - Portland · USUniversity of California, Los Angeles · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ROSENMUND, CHRISTIAN · 1988 to 2013
$29.4M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Project 3: Collagen post-translational modification and cross-linking in OIP01HD070394 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI KRAKOW, DEBORAH · 2011 to 2020
$13.4M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Collagen Cross-linking in Skeletal Aging and DiseaseR37AR037318 · NIAMS · UNIVERSITY OF WASHINGTON · PI EYRE, DAVID R · 2010 to 2019
$3.4M
PATHOLOGY OF INBORN SKELETAL DISEASESR01AR037318 · NIAMS · UNIVERSITY OF WASHINGTON · PI EYRE, DAVID R · 1986 to 2009
$3.4M
WNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal TissuesR01DE031162 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, PARK, DONGSU · 2021 to 2025
$2.9M
Defining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
The function of FKBP10 in Osteogenesis Imperfecta and Bruck syndromeF32AR070612 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI LIM, JOOHYUN · 2017 to 2019
$179k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIAMS NIH HHS F32 AR070612NIAMS NIH HHS R01 AR037318NIAMS NIH HHS R01 AR072018NIAMS NIH HHS R37 AR037318NICHD NIH HHS P01 HD070394NICHD NIH HHS P30 HD024064NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDCR NIH HHS R01 DE031162
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is a genetic disorder that features wide-ranging defects in both skeletal and nonskeletal tissues. Previously, we and others reported that loss-of-function mutations in FK506 Binding Protein 10 (

Indexed as

Motor ActivityOsteogenesisAnimalsAnimals, NewbornChondrocytesChondrogenesisCollagen Type IDisease Models, AnimalFibrosisGaitGene DeletionGene Expression RegulationHedgehog ProteinsHydroxylationInflammationJointsCollagen Type Icollagen type I trimeric cross-linked peptideFkbp10 protein, mouseHedgehog ProteinsLysinePeptidesTacrolimus Binding ProteinscontractureFkbp10ligamentosteogenesis imperfectatendon

Identifiers

PMID34161280
PMCPMC8237619
OpenAlexW3166512458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.