ArticleProceedings of the National Academy of Sciences of the United States of America2021
Electrochemical quantification of accelerated FADGDH rates in aqueous nanodroplets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Measuring the Dynamic Nanometric Contact Radius of a Single Microdroplet on an Electrified Microinterface.Angewandte Chemie (International ed. in English) · 2026Article
- Radical Electroprecipitation from a Water|Oil|Electrode Interface Prolongs "Electro"Chemiluminescence of the Tris(2,2'-bipyridyl)Ruthenium(II) and Benzoyl Peroxide System by 10Angewandte Chemie (International ed. in English) · 2026Article
- Multiphase Electrochemiluminescence of Microdroplets and Radical Salts.Accounts of chemical research · 2025Article
- Real-Time Visualization of an Elusive, Strong Reducing Agent during Tris(2,2'-bipyridyl)ruthenium(II) Electro-Oxidation in Water.Journal of the American Chemical Society · 2025Article
- Are redox catalytic reaction rates accelerated in microdroplets on electrode surfaces?Journal of solid state electrochemistry : current research and development in science and technology · 2025Article
- The gas|liquid interface eclipses the liquid|liquid interface for glucose oxidase rate acceleration in microdroplets.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Enhanced Electrochemiluminescence at the Gas/Liquid Interface of Bubbles Propelled into Solution.Journal of the American Chemical Society · 2024Article
- Reaction acceleration at the surface of a levitated droplet by vapor dosing from a partner droplet.Chemical science · 2024Article
- Amplifying the electrochemical footprint of <1000 molecules in a dissolving microdroplet.The Analyst · 2024Article
- Femtoliter oil droplets act as COJournal of colloid and interface science · 2024Article
- Direct electrochemical evidence suggests that aqueous microdroplets spontaneously produce hydrogen peroxide.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The pluses and minuses of microdroplet separation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Triple-Barrel Ultramicroelectrodes for Multipurpose, Submilliliter Electroanalysis.Analytical chemistry · 2023Article
- Interfacial solute flux promotes emulsification at the water|oil interface.Nature communications · 2023Article
- Spatial reorganization of analytes in charged aqueous microdroplets.Chemical science · 2022Article
- Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair.Angewandte Chemie (International ed. in English) · 2022Article
- Oxidation of Cysteine by Electrogenerated Hexacyanoferrate(III) in Microliter Droplets.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Preferential Electroreduction at the Oil|Water|Conductor Interface.The journal of physical chemistry letters · 2022Article
- Versatile potentiometric metabolite sensing without dioxygen interference.Biosensors & bioelectronics · 2022Article
- Spontaneous Water Radical Cation Oxidation at Double Bonds in Microdroplets.Frontiers in chemistry · 2022Article
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Authors and funding
4 authors.
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Abstract
Enzymes are molecules that catalyze reactions critical to life. These catalysts are often studied in bulk water, where the influence of water volume on reactivity is neglected. Here, we demonstrate rate enhancement of up to two orders of magnitude for enzymes trapped in submicrometer water nanodroplets suspended in 1,2-dichloroethane. When single nanodroplets irreversibly adsorb onto an ultramicroelectrode surface, enzymatic activity is apparent in the amperometric current-time trace if the ultramicroelectrode generates the enzyme cofactor. Nanodroplet volume is easily accessible by integrating the current-time response and using Faraday's Law. The single nanodroplet technique allows us to plot the enzyme's activity as a function of nanodroplet size, revealing a strong inverse relationship. Finite element simulations confirm our experimental results and offer insights into parameters influencing single nanodroplet enzymology. These results provide a framework to profoundly influence the understanding of chemical reactivity at the nanoscale.
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