Evidence map›Paper›PMID 34161270›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Potency boost of a

Wassihun Wedajo Aragaw, Brendon M Lee, Xuan Yang, Matthew D Zimmerman, Martin Gengenbacher, Véronique Dartois, Wai-Keung Chui, Colin J Jackson, Thomas Dick

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Wassihun Wedajo AragawCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.ORCID 0000-0002-4199-2224
Brendon M LeeResearch School of Chemistry, The Australian National University, Acton 2601, Australia.ORCID 0000-0001-6476-5246
Xuan YangDepartment of Pharmacy, Faculty of Science, National University of Singapore, 117543 Singapore, Singapore.ORCID 0000-0002-3480-9065
Matthew D ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Martin GengenbacherCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.ORCID 0000-0001-9470-5009
Wai-Keung ChuiDepartment of Pharmacy, Faculty of Science, National University of Singapore, 117543 Singapore, Singapore.
Colin J JacksonResearch School of Chemistry, The Australian National University, Acton 2601, Australia; colin.jackson@anu.edu.au thomas.dick@hmh-cdi.org.
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110; colin.jackson@anu.edu.au thomas.dick@hmh-cdi.org.ORCID 0000-0002-9604-9452
Hackensack Meridian Health · USNational University of Singapore · SGAustralian National University · AU

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
NIAID NIH HHS R01 AI132374NIH HHS S10 OD023524
6 · The paper itself

Abstract

Triaza-coumarin (TA-C) is a

Indexed as

CoumarinsDrug Resistance, BacterialFolic AcidFolic Acid AntagonistsGenes, BacterialLoss of Function MutationMolecular Docking SimulationMultienzyme ComplexesMycobacterium tuberculosisOxidation-ReductionOxidoreductasesTetrahydrofolate DehydrogenasecoumarinCoumarinsF420H2 dehydrogenaseFolic AcidFolic Acid AntagonistsMultienzyme ComplexesOxidoreductasesTetrahydrofolate DehydrogenaseantibacterialDHFRF420Mycobacterium tuberculosis

Identifiers

PMID34161270
PMCPMC8237569
OpenAlexW3171270764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.