ArticleProceedings of the National Academy of Sciences of the United States of America2021
Early role for a Na
Open access · greenAbstract readCase Reports
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
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- Feeding All-Trans Retinoic Acid to Pregnant Sows Regulates the Development of the Pulmonary Nervous Systems of Neonatal Pigs.Veterinary sciences · 2026Article
- RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death.Nature communications · 2026Article
- Human milk oligosaccharides promote synaptogenesis and neurite outgrowth in human cortical organoids.Biochemistry and biophysics reports · 2026Article
- Serum potassium and high-altitude coronary microvascular disease: a propensity score matched analysis revealing a linear dose-response relationship.Frontiers in pharmacology · 2026Article
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- A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders.Cell stem cell · 2025Article
- Pathogenic Variants inNeurology. Genetics · 2025Article
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- Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice.Neurobiology of disease · 2025Article
- Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex.Nature neuroscience · 2025Article
- Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells.Frontiers in molecular neuroscience · 2025Article
- Case Report: A case of Poirier-Bienvenu neurodevelopmental syndrome manifesting primarily as eyelid myoclonia.Frontiers in pediatrics · 2025Article
- Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet.Frontiers in nutrition · 2025Article
- Gallic acid attenuates lipopolysaccharide - induced memory deficits, neurochemical changes, and peripheral alterations in purinergic signaling.Metabolic brain disease · 2024Article
- Characterization of lncRNA and mRNA profiles in the process of repairing peripheral nerve defects with cell-matrixed nerve grafts.BMC genomics · 2024Article
- Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome.EMBO molecular medicine · 2024Article
- Gene regulatory landscape of cerebral cortex folding.Science advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 3 countries.
Richard S SmithDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115; richard.smith@childrens.harvard.edu christopher.walsh@childrens.harvard.edu.ORCID 0000-0003-1937-6529
Marta FlorioDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-6168-005X
Shyam K AkulaDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-2334-591X
Jennifer E NeilDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115.
Yidi WangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-2384-3812
R Sean HillDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115.
Melissa GoldmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Christopher D MullallyDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Nora ReedDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Luis Bello-EspinosaArnold Palmer Hospital for Children, Orlando, FL 32806.ORCID 0000-0001-9230-0649
Laura Flores-SarnatDepartment of Paediatrics and Clinical Neurosciences, The Owerko Centre, University of Calgary and Alberta Children's Hospital Research Institute, Calgary, AB T2N 1N4, Canada.
Fabiola Paoli MonteiroMendelics Genomic Analysis, CEP 04013-000 São Paulo, Brazil.
Casella B ErasmoChildren's Institute, Hospital das Clinicas, CEP 05403-000 São Paulo, Brazil.ORCID 0000-0003-0834-9664
Filippo Pinto E VairoCenter for Individualized Medicine, Mayo Clinic, Rochester, MN 55905.ORCID 0000-0001-6030-1903
Eva MoravaChildren's Institute, Hospital das Clinicas, CEP 05403-000 São Paulo, Brazil.
A James BarkovichDepartment of Radiology, Benioff Children's Hospital, University of California, San Francisco, CA 94117.ORCID 0000-0003-4291-7346
Joseph Gonzalez-HeydrichDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3073-983X
Catherine A BrownsteinDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115.
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Howard Hughes Medical Insitute, Boston Children's Hospital, Boston, MA 02115; richard.smith@childrens.harvard.edu christopher.walsh@childrens.harvard.edu.ORCID 0000-0002-0156-2238
Broad Institute · USArnold Palmer Hospital for Children · USBoston Children's Hospital · USMayo Clinic · USMendelics · BRUniversity of Calgary · CAUniversity of California, San Francisco · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MJoint Center for Mendelian GenomicsUM1HG008900 · NHGRI · BROAD INSTITUTE, INC. · PI O'DONNELL-LURIA, ANNE, REHM, HEIDI L · 2016 to 2020
$16.5MCell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7MHUMAN EPILEPSY GENETICS--NEURONAL MIGRATION DISORDERSR01NS035129 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WALSH, CHRISTOPHER A. · 1997 to 2023
$9.5MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2MRole for ion conducting proteins in cortical malformation diseasesK99NS112604 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI SMITH, RICHARD S · 2019 to 2021
$276kNHGRI NIH HHS UM1 HG008900NICHD NIH HHS U54 HD090255NIGMS NIH HHS T32 GM007753NINDS NIH HHS K99 NS112604NINDS NIH HHS R01 NS032457NINDS NIH HHS R01 NS035129
Abstract
Osmotic equilibrium and membrane potential in animal cells depend on concentration gradients of sodium (Na
Indexed as
AdultBrainChildFemaleFetusGene Expression Regulation, DevelopmentalHumansInfantInfant, NewbornInterneuronsMagnetic Resonance ImagingMaleMutationNeocortexNeuronsParvalbuminsATP1A3 protein, humanParvalbuminsRNA, MessengerSodium-Potassium-Exchanging ATPaseATP1A3cortex developmentcortical malformationdevelopmental channelopathypolymicrogyria
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.