Evidence map›Paper›PMID 34161260›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The human gut microbiome and health inequities.

Katherine R Amato, Marie-Claire Arrieta, Meghan B Azad, Michael T Bailey, Josiane L Broussard, Carlijn E Bruggeling, Erika C Claud, Elizabeth K Costello, Emily R Davenport, Bas E Dutilh and 13 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. COVID-19 alters human microbiomes: a meta-analysis.Frontiers in cellular and infection microbiology · 2023
    Pooled it
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  6. Introducing theJournal of marriage and the family · 2026
    Article
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  8. Observational
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  20. Doing Science With Our Grandmother's WISDOM: A Worldview Integrating Sociality, Diversity, and Observant Meaning-Making.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Katherine R AmatoDepartment of Anthropology, Northwestern University, Evanston, IL 60208; katherine.amato@northwestern.edu.ORCID 0000-0003-2722-9414
Marie-Claire ArrietaDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Meghan B AzadChildren's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.ORCID 0000-0002-5942-4444
Michael T BaileyCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205.
Josiane L BroussardDepartment of Health and Exercise Science, Colorado State University, Fort Collins, CO 80521.ORCID 0000-0002-6824-8294
Carlijn E BruggelingDepartment of Pathology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0002-6714-6878
Erika C ClaudDepartment of Pediatrics, The University of Chicago, Chicago, IL 60637.
Elizabeth K CostelloDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Emily R DavenportDepartment of Biology, Huck Institutes of the Life Sciences, Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-6938-4933
Bas E DutilhTheoretical Biology and Bioinformatics, Science for Life, Utrecht University, 3584 CH Utrecht, The Netherlands.ORCID 0000-0003-2329-7890
Holly A Swain EwaldDepartment of Biology, University of Louisville, Louisville, KY 40292.ORCID 0000-0002-7930-5194
Paul EwaldDepartment of Biology, University of Louisville, Louisville, KY 40292.ORCID 0000-0003-3979-0460
Erin C HanlonDepartment of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL 60637.
Wrenetha JulionCollege of Nursing, Rush University, Chicago, IL 60612.
Ali KeshavarzianRush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612.ORCID 0000-0002-7969-3369
Corinne F MauriceMicrobiology and Immunology Department, McGill University, Montreal, QC H3A 2B4, Canada.
Gregory E MillerDepartment of Psychology, Northwestern University, Evanston, IL 60208.
Geoffrey A PreidisSection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030.ORCID 0000-0002-2206-6452
Laure SegurelEco-anthropologie, Muséum National d'Histoire Naturelle-CNRS-Université de Paris, 75016 Paris, France.ORCID 0000-0001-7339-0976
Burton SingerEmerging Pathogens Institute, University of Florida, Gainesville, FL 32608.ORCID 0000-0002-5295-5971
Sathish SubramanianDepartment of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-4341-8592
Liping ZhaoState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Christopher W KuzawaDepartment of Anthropology, Northwestern University, Evanston, IL 60208.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI BARREIRO, LUIS BRUNO · 1990 to 2025
$29.8M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Time-restricted feeding to mitigate metabolic impairments during circadian misalignmentR01DK125653 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2020 to 2024
$3.3M
Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutritionK08DK113114 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PREIDIS, GEOFFREY A · 2017 to 2021
$815k
Effects of physical activity on cardiometabolic impairments associated with insufficient sleepK01DK110138 · NIDDK · UNIVERSITY OF COLORADO · PI BROUSSARD, JOSIANE · 2016 to 2018
$484k
NIDDK NIH HHS K01 DK110138NIDDK NIH HHS K08 DK113114NIDDK NIH HHS P30 DK042086NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK125653NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome is strongly shaped by host environments and affects host metabolic, immune, and neuroendocrine functions, making it an important pathway by which differences in experiences caused by social, political, and economic forces could contribute to health inequities. Nevertheless, few studies have directly integrated the gut microbiome into investigations of health inequities. Here, we argue that accounting for host-gut microbe interactions will improve understanding and management of health inequities, and that health policy must begin to consider the microbiome as an important pathway linking environments to population health.

Indexed as

Gastrointestinal MicrobiomeHealth Status DisparitiesDiseaseHealthHumansMental HealthPublicationschronic diseaseDOHadhealth disparitiespolicystructural racism

Identifiers

PMID34161260
PMCPMC8237592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.