Evidence map›Paper›PMID 34161259›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice.

Tianfei Hou, Wen Su, Marilyn J Duncan, Vsevolozhskaya A Olga, Zhenheng Guo, Ming C Gong

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Multiple oscillators underlie circadian food anticipation in mice.Neurobiology of sleep and circadian rhythms · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tianfei HouDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0002-4102-2615
Wen SuDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0003-1057-9469
Marilyn J DuncanDepartment of Neuroscience, University of Kentucky, Lexington, KY 40536.ORCID 0000-0002-6298-9016
Vsevolozhskaya A OlgaDepartment of Biotatistics, University of Kentucky, Lexington, KY 40536.
Zhenheng GuoDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536; zguo2@uky.edu ming.gong@uky.edu.ORCID 0000-0002-9729-3211
Ming C GongDepartment of Physiology, University of Kentucky, Lexington, KY 40536 zguo2@uky.edu ming.gong@uky.edu.ORCID 0000-0002-3554-7378
University of Kentucky · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
A novel mechanism by which smooth muscle BMAL1 regulates IL-6 and sexual dimorphism of abdominal aortic aneurysmR01HL142973 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2018 to 2021
$2.6M
Targeting timing of food intake as a novel strategy against disruption of blood pressure circadian rhythm in diabetesR01HL141103 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2019 to 2022
$2.5M
Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1R01HL106843 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2012 to 2015
$2.0M
iPLA2 as a Target in Vascular Inflammation, Neointima Formation, and RestenosisI01BX002141 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI GUO, ZHENHENG · 2015 to 2018
–
BLRD VA I01 BX002141NHLBI NIH HHS R01 HL106843NHLBI NIH HHS R01 HL141103NHLBI NIH HHS R01 HL142973NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes are not fully understood. Here, we report that food intake and BP were arrhythmic in diabetic

Indexed as

AnimalsBlood PressureCircadian RhythmDiabetes Mellitus, ExperimentalEnergy IntakeFastingMiceSympathetic Nervous SystemTime Factorsblood pressure circadian rhythmdiabetesnondipping blood pressuresympathetic nervous systemtime-restricted feeding

Identifiers

PMID34161259
PMCPMC8237651
OpenAlexW3169305962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.