Evidence map›Paper›PMID 34161229›Full record

ArticleeLife2021

Multiple pathways of toxicity induced by

Frédéric Frottin, Manuela Pérez-Berlanga, F Ulrich Hartl, Mark S Hipp

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Microprotein Regulates G-quadruplex Driven RNA Aggregation.bioRxiv : the preprint server for biology · 2026
    Article
  4. Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Emerging Connections between Nuclear Pore Complex Homeostasis and ALS.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frédéric FrottinMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-2756-7838
Manuela Pérez-BerlangaMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0001-9064-9724
F Ulrich HartlMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-7941-135X
Mark S HippMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-0497-3016

Funding

EMBO Long term fellowshipEuropean Commission FP7 GA ERC-2012-SyG_318987-ToPAGFederal Ministry of Education and Research 01PL17016
6 · The paper itself

Abstract

The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G

Indexed as

RNA TransportC9orf72 ProteinDipeptidesHumansRNAC9orf72 ProteinC9orf72 protein, humanDipeptidesRNAbiochemistrychemical biologyhumanneurodegenerationneuroscienceprotein aggregationquality control

Identifiers

PMID34161229
PMCPMC8221807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.