Evidence map›Paper›PMID 34161154›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Increased intracellular Cl

Hui Sun, Omkar Paudel, James S K Sham

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hui SunDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Omkar PaudelDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
James S K ShamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-3571-8712
Johns Hopkins University · US

Funding

Ca regulation in chronic hypoxic pulmonary hypertensionR01HL075134 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SHAM, JAMES SK · 2004 to 2013
$3.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 HL-075134NHLBI NIH HHS R01 HL075134
6 · The paper itself

Abstract

Chloride channels play an important role in regulating smooth muscle contraction and proliferation, and contribute to the enhanced constriction of pulmonary arteries (PAs) in pulmonary hypertension (PH). The intracellular Cl

Indexed as

AnimalsCalciumCell HypoxiaChloride ChannelsHypertension, PulmonaryHypoxiaMuscle, Smooth, VascularMyocytes, Smooth MusclePulmonary ArteryRatsCalciumChloride ChannelsCl− homeostasisCl− transportersintracellular Cl− concentrationpulmonary hypertension

Identifiers

PMID34161154
PMCPMC8526344
OpenAlexW3174649849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.