Evidence map›Paper›PMID 34161070›Full record

ArticleBioconjugate chemistry2021

Characterization of Intrinsically Radiolabeled Poly(lactic-

Massis Krekorian, Gerwin G W Sandker, Kimberley R G Cortenbach, Oya Tagit, N Koen van Riessen, René Raavé, Mangala Srinivas, Carl G Figdor, Sandra Heskamp, Erik H J G Aarntzen

Open access · bronzeAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Homotypic Targeting of [Pharmaceutics · 2025
    Article
  3. Review
  4. Polymeric (Poly(lactic-ACS omega · 2025
    Article
  5. In Vitro Assessment ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Massis KrekorianDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5812-866X
Gerwin G W SandkerDepartment of Medical Imaging, Radboud Institute for Molecular Life Sciences, Radboud university Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Kimberley R G CortenbachDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.
Oya TagitDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5773-6647
N Koen van RiessenDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.
René RaavéDepartment of Medical Imaging, Radboud Institute for Molecular Life Sciences, Radboud university Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Mangala SrinivasDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-3835-1995
Carl G FigdorDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.
Sandra HeskampDepartment of Medical Imaging, Radboud Institute for Molecular Life Sciences, Radboud university Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-7250-0846
Erik H J G AarntzenDepartment of Medical Imaging, Radboud Institute for Molecular Life Sciences, Radboud university Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the advent of novel immunotherapies, interest in ex vivo autologous cell labeling for in vivo cell tracking has revived. However, current clinically available labeling strategies have several drawbacks, such as release of radiolabel over time and cytotoxicity. Poly(lactic-

Indexed as

Cell TrackingAminesAnimalsCell SurvivalFemaleHumansMiceNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerRadiopharmaceuticalsTHP-1 CellsAminesPolylactic Acid-Polyglycolic Acid CopolymerRadiopharmaceuticals

Identifiers

PMID34161070
PMCPMC8377710
OpenAlexW3173931891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.