ArticlePlant biotechnology journal2021
A large-scale genomic association analysis identifies a fragment in Dt11 chromosome conferring cotton Verticillium wilt resistance.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 52 citations in OpenAlex.
- Multiple environmental test and genetic mapping jointly reveal genomic loci and associated genes underlying cotton Verticillium wilt resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- Development of a Liquid-Phased Probe Array for Upland Cotton and Its Application in Cultivar Identification.Genes · 2025Article
- Article
- A panoramic view of cotton resistance toiMeta · 2025Article
- Unraveling key genes and pathways involved in Verticillium wilt resistance by integrative GWAS and transcriptomic approaches in Upland cotton.Functional & integrative genomics · 2025Article
- Cotton RLP6 Interacts With NDR1/HIN6 to Enhance Verticillium Wilt Resistance via Altering ROS and SA.Molecular plant pathology · 2025Article
- Genome-Wide Identification and Analysis of theGenes · 2024Article
- The complex relationship between disease resistance and yield in crops.Plant biotechnology journal · 2024Review
- Transcriptome analysis of Gossypium hirsutum cultivar Zhongzhimian No.2 uncovers the gene regulatory networks involved in defense against Verticillium dahliae.BMC plant biology · 2024Article
- Genome-Wide and Expression Pattern Analysis of the HIT4 Gene Family Uncovers the Involvement ofGenes · 2024Article
- Genome-Wide Identification and Analysis of the WNK Kinase Gene Family in Upland Cotton.Plants (Basel, Switzerland) · 2023Article
- Uncovering genomic and transcriptional variations facilitates utilization of wild resources in cotton disease resistance improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Lysine 2-Hydroxyisobutyrylation- and Succinylation-Based Pathways Act Inside Chloroplasts to Modulate Plant Photosynthesis and Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Unraveling genomic regions and candidate genes for multiple disease resistance in upland cotton using meta-QTL analysis.Heliyon · 2023Article
- Genome-wide association study reveals novel SNPs and genes in Gossypium hirsutum underlying Aphis gossypii resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-wide association analysis reveals a novel pathway mediated by a dual-TIR domain protein for pathogen resistance in cotton.Genome biology · 2023Article
- Genome-wide association study of fiber yield-related traits uncovers the novel genomic regions and candidate genes in Indian upland cotton (Frontiers in plant science · 2023Article
- A Novel Intelligent System for Dynamic Observation of Cotton Verticillium Wilt.Plant phenomics (Washington, D.C.) · 2023Article
- Genome-wide analysis of serine carboxypeptidase-like protein (SCPL) family and functional validation of Gh_SCPL42 unchromosome conferring cotton Verticillium der Verticillium wilt stress in Gossypium hirsutum.BMC plant biology · 2022Article
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Authors and funding
17 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Verticillium wilt (VW) is a destructive disease that results in great losses in cotton yield and quality. Identifying genetic variation that enhances crop disease resistance is a primary objective in plant breeding. Here we reported a GWAS of cotton VW resistance in a natural-variation population, challenged by different pathogenicity stains and different environments, and found 382 SNPs significantly associated with VW resistance. The associated signal repeatedly peaked in chromosome Dt11 (68 798 494-69 212 808) containing 13 core elite alleles undescribed previously. The core SNPs can make the disease reaction type from susceptible to tolerant or resistant in accessions with alternate genotype compared to reference genotype. Of the genes associated with the Dt11 signal, 25 genes differentially expressed upon Verticillium dahliae stress, with 21 genes verified in VW resistance via gene knockdown and/or overexpression experiments. We firstly discovered that a gene cluster of L-type lectin-domain containing receptor kinase (GhLecRKs-V.9) played an important role in VW resistance. These results proved that the associated Dt11 region was a major genetic locus responsible for VW resistance. The frequency of the core elite alleles (FEA) in modern varieties was significantly higher than the early/middle varieties (12.55% vs 4.29%), indicating that the FEA increased during artificial selection breeding. The current developmental resistant cultivars, JND23 and JND24, had fixed these core elite alleles during breeding without yield penalty. These findings unprecedentedly provided genomic variations and promising alleles for promoting cotton VW resistance improvement.
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