Evidence map›Paper›PMID 34160751›Full record

ReviewJournal of molecular neuroscience : MN2021

Protective Effects of Zinc on Spinal Cord Injury.

Shan Wen, Yuanlong Li, Xiaolei Shen, Zhe Wang, Kaihua Zhang, Jiawei Zhang, Xifan Mei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.Oxidative medicine and cellular longevity · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Iron Metabolism and Ferroptosis in Peripheral Nerve Injury.Oxidative medicine and cellular longevity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shan WenDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Yuanlong LiDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Xiaolei ShenDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Zhe WangDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Kaihua ZhangDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Jiawei ZhangDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Xifan MeiDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China. meixifan@jzmu.edu.cn.ORCID http://orcid.org/0000-0002-4452-8005
Jinzhou Medical University · CNAffiliated Hospital of Jining Medical University · CN

Funding

National Natural Science Foundation of China 81871556National Natural Science Foundation of China 82072165
6 · The paper itself

Abstract

Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.

Indexed as

AnimalsAutophagyHumansNeuronsNeuroprotective AgentsOxidative StressSpinal Cord InjuriesZincNeuroprotective AgentsZincAutophagyInflammationNeuronOxidative stressSpinal cord injuryZinc

Identifiers

PMID34160751
OpenAlexW3173880785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.