Evidence map›Paper›PMID 34160243›Full record

ArticlemSphere2021

Intravital Imaging of Candida albicans Identifies Differential

Rohan S Wakade, Manning Huang, Aaron P Mitchell, Melanie Wellington, Damian J Krysan

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  3. Article
  4. Rapid and simple detection ofFrontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Temporal dynamics ofmSphere · 2024
    Article
  7. The role of themSphere · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Significant variation of filamentation phenotypes in clinicalFrontiers in cellular and infection microbiology · 2023
    Article
  14. Article
  15. Evaluation of Anti-Journal of fungi (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rohan S WakadeDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
Manning HuangDepartment of Biological Sciences, grid.147455.6Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Aaron P MitchellDepartment of Biological Sciences, grid.147455.6Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Melanie WellingtonDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
Damian J KrysanDepartment of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.
University of Iowa · USCarnegie Mellon University · USUniversity of Georgia · US

Funding

Functional Analysis of Natural Variation in the Pathogen Candida albicansR01AI146103 · NIAID · UNIVERSITY OF GEORGIA · PI MITCHELL, AARON P · 2019 to 2023
$2.6M
Complex haploinsufficiency based genetic analysis of C. albicans pathogenesisR01AI133409 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J · 2018 to 2022
$2.5M
NIAID NIH HHS R01 AI133409NIAID NIH HHS R01 AI146103
6 · The paper itself

Abstract

Candida albicans is an important cause of human fungal infections. A widely studied virulence trait of C. albicans is its ability to undergo filamentation to hyphae and pseudohyphae. Although yeast, pseudohyphae, and hyphae are present in pathological samples of infected mammalian tissue, it has been challenging to characterize the role of regulatory networks and specific genes during

Indexed as

MutationPhenotypeAnimalsCandida albicansCandidiasisEarFemaleFungal ProteinsGene Expression Regulation, FungalHumansHyphaeIntravital MicroscopyIn Vitro TechniquesMiceTranscription FactorsFungal ProteinsTranscription FactorsCandida albicanshyphaeintravital imagingtranscription factors

Identifiers

PMID34160243
PMCPMC8265662
OpenAlexW3164944640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.