Evidence map›Paper›PMID 34160238›Full record

ArticlemSphere2021

Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata.

Mark V Horton, Chad J Johnson, Robert Zarnowski, Brody D Andes, Taylor J Schoen, John F Kernien, Douglas Lowman, Michael D Kruppa, Zuchao Ma, David L Williams and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  11. Review
  12. Article
  13. bioRxiv : the preprint server for biology · 2026
    Article
  14. Frontiers in cellular and infection microbiology · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. The GPI-Anchored Aspartyl Proteases Encoded by theJournal of fungi (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mark V HortonDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Chad J JohnsonDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Robert ZarnowskiDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Brody D AndesDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Taylor J SchoenDepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
John F KernienDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Douglas LowmanDepartment of Surgery, Center for Inflammation, Infectious Disease and Immunity, East Tennessee State Universitygrid.255381.8, Johnson City, Tennessee, USA.
Michael D KruppaDepartment of Biomedical Sciences, Center for Inflammation, Infectious Disease and Immunity, East Tennessee State Universitygrid.255381.8, Johnson City, Tennessee, USA.
Zuchao MaDepartment of Surgery, Center for Inflammation, Infectious Disease and Immunity, East Tennessee State Universitygrid.255381.8, Johnson City, Tennessee, USA.
David L WilliamsDepartment of Surgery, Center for Inflammation, Infectious Disease and Immunity, East Tennessee State Universitygrid.255381.8, Johnson City, Tennessee, USA.
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
Jeniel E NettDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USEast Tennessee State University · US

Funding

Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
Mechanism(s) of pathogenicity for Candida aurisR01AI145939 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2020 to 2025
$2.7M
Characterizing Candida auris skin colonization and high-burden biofilm formationR21AI159583 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2021 to 2022
$427k
Genetic Characterization of phosphomannan biosynthesis in C. aurisR21AI159877 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI KRUPPA, MICHAEL D · 2021 to 2022
$407k
Doris Duke Charitable Foundation 2017074NIAID NIH HHS R01 AI145939NIAID NIH HHS R21 AI159583NIAID NIH HHS R21 AI159877NIAID NIH HHS T32 AI055397NIA NIH HHS T32 AG000213NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197
6 · The paper itself

Abstract

Candida auris, a recently emergent fungal pathogen, has caused invasive infections in health care settings worldwide. Mortality rates approach 60% and hospital spread poses a public health threat. Compared to other

Indexed as

Immune EvasionAnimalsCandida albicansCandida aurisCandida glabrataCell WallMannansNeutrophilsPhagocytosisVirulenceZebrafishMannansCandidaCandida auriscell wallglucan maskingimmune evasioninnate immunitymannanneutrophilRac2

Identifiers

PMID34160238
PMCPMC8265655
OpenAlexW3177114916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.