Evidence map›Paper›PMID 34160237›Full record

ArticlemSphere2021

Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization.

Krishna Rao, Alieysa Patel, Yuang Sun, Jay Vornhagen, Jonathan Motyka, Abigail Collingwood, Alexandra Teodorescu, Ji Hoon Baang, Lili Zhao, Keith S Kaye and 1 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Effective macrophage clearance ofbioRxiv : the preprint server for biology · 2026
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  8. A Novel Technique to CharacterizebioRxiv : the preprint server for biology · 2025
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  12. mBio · 2025
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  13. Review
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  15. Article
  16. Effect of Meropenem on Conjugative Plasmid Transfer inInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Krishna RaoDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Alieysa PatelDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Yuang SunDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Jay VornhagenDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Jonathan MotykaDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Abigail CollingwoodDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Alexandra TeodorescuDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Ji Hoon BaangDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Lili ZhaoDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Keith S KayeDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
Michael A BachmanDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
University of Michigan · USMichigan Medicine · US

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Integrated modeling of Klebsiella pneumoniae infections based on bacterial genotype, patient factors and colonization statusR01AI125307 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BACHMAN, MICHAEL ABBOTT · 2017 to 2021
$2.6M
NIAID NIH HHS R01 AI125307NIAID NIH HHS T32 AI007528
6 · The paper itself

Abstract

Klebsiella commonly colonizes the intestinal tract of hospitalized patients and is a leading cause of health care-associated infections. Colonization is associated with subsequent infection, but the factors determining this progression are unclear. A cohort study was performed, in which intensive care and hematology/oncology patients with Klebsiella colonization based on rectal swab culture were enrolled and monitored for infection for 90 days after a positive swab. Electronic medical records were analyzed for patient factors associated with subsequent infection, and variables of potential significance in a bivariable analysis were used to build a final multivariable model. Concordance between colonizing and infecting isolates was assessed by

Indexed as

AdultAgedAged, 80 and overCohort StudiesComorbidityDepressionFemaleHematologic NeoplasmsHumansIntensive Care UnitsKlebsiella InfectionsKlebsiella pneumoniaeMaleMiddle AgedRectumRisk Factorscohort studyinfection riskintestinal colonizationKlebsiellamultivariable model

Identifiers

PMID34160237
PMCPMC8265626
OpenAlexW3177195248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.