Evidence map›Paper›PMID 34160235›Full record

ArticlemSphere2021

Reversing Antibiotic Resistance Caused by Mobile Resistance Genes of High Fitness Cost.

Jinyong Wu, Xiaohong Dong, Lihua Zhang, Yufei Lin, Kun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Molecular Basis of Persister Awakening and Lag-Phase Recovery inInternational journal of molecular sciences · 2026
    Review
  2. Heterogeneous subpopulations inFrontiers in cellular and infection microbiology · 2025
    Article
  3. Article
  4. Review
  5. Occurrence and Biological Cost ofAntibiotics (Basel, Switzerland) · 2022
    Article
  6. Whole-Genome Sequencing Reveals Diversity of Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinyong Wu *Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan Universitygrid.13291.38, Chengdu, China.
Xiaohong Dong *Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan Universitygrid.13291.38, Chengdu, China.
Lihua ZhangDepartment of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan Universitygrid.13291.38, Chengdu, China.
Yufei LinDepartment of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan Universitygrid.13291.38, Chengdu, China.
Kun YangDepartment of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan Universitygrid.13291.38, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reversibility of antibiotic resistance is theoretically attractive due to the prospect of restoring the clinical potency of antibiotics. It is important to find out the factors that affect the reversibility of antibiotic resistance. Here, an

Indexed as

Genetic FitnessAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsPlasmidsWhole Genome SequencingAnti-Bacterial AgentsEscherichia coli ProteinsMCR-1 protein, E coliantibiotic resistance genesfitness costmcr-1multidrug resistanceqPCRreversibility

Identifiers

PMID34160235
PMCPMC8265650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.