Evidence map›Paper›PMID 34160233›Full record

Observational studymSphere2021

Association of Diverse Staphylococcus aureus Populations with Pseudomonas aeruginosa Coinfection and Inflammation in Cystic Fibrosis Airway Infection.

Marie K Wieneke, Felix Dach, Claudia Neumann, Dennis Görlich, Lena Kaese, Theo Thißen, Angelika Dübbers, Christina Kessler, Jörg Große-Onnebrink, Peter Küster and 11 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Microenvironment shapesiScience · 2026
    Article
  2. BioMed research international · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Experimentally evolvedMicrobiology (Reading, England) · 2024
    Article
  7. NorA efflux pump mediatesAntimicrobial agents and chemotherapy · 2024
    Article
  8. A bacterial pigment provides cross-species protection from HProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Anti-Biofilm Activity of Carnosic Acid fromPlants (Basel, Switzerland) · 2023
    Article
  11. Antibiotics (Basel, Switzerland) · 2023
    Article
  12. HowInternational journal of molecular sciences · 2023
    Review
  13. Biofilm Formation byInternational journal of molecular sciences · 2022
    Review
  14. Article
  15. Review
  16. Pathogens (Basel, Switzerland) · 2021
    Review
  17. Biofilm Formation in Methicillin-ResistantFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Marie K Wieneke *Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Felix Dach *Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Claudia NeumannInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Dennis GörlichInstitute of Biostatistics and Clinical Research, University Hospital Münster, Münster, Germany.
Lena KaeseInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Theo ThißenInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Angelika DübbersDepartment of Pediatrics, University Hospital Münster, Münster, Germany.
Christina KesslerDepartment of Pediatrics, University Hospital Münster, Münster, Germany.
Jörg Große-OnnebrinkDepartment of Pediatrics, University Hospital Münster, Münster, Germany.
Peter KüsterDepartment of Pediatrics, Clemenshospital Münster, Münster, Germany.
Holger SchültingkemperDepartment of Pediatrics, Clemenshospital Münster, Münster, Germany.
Bianca SchwartbeckInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Johannes RothInstitute of Immunology, University Hospital Münster, Münster, Germany.
Jerzy-Roch NoferCentral Laboratory Facility, University Hospital Münster, Münster, Germany.
Janina TreffonInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Julia PosdorferInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Josefine Marie BoeckenInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Mariele StrakeInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Miriam AbdoInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Sophia WesthuesInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Barbara C KahlInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
University Hospital Münster · DEClemenshospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is one of the most common pathogens isolated from the airways of cystic fibrosis (CF) patients and often persists for extended periods. There is limited knowledge about the diversity of S. aureus in CF. We hypothesized that increased diversity of S. aureus would impact CF lung disease. Therefore, we conducted a 1-year observational prospective study with 14 patients with long-term S. aureus infection. From every sputum, 40 S. aureus isolates were chosen and characterized in terms of phenotypic appearance (size, hemolysis, mucoidy, and pigmentation), important virulence traits such as nuclease activity, biofilm formation, and molecular typing by

Indexed as

Adaptation, PhysiologicalAdolescentAdultBiofilmsCoinfectionCystic FibrosisFemaleGenotypeHumansInflammationMaleMiddle AgedPhenotypeProspective StudiesPseudomonas aeruginosaPseudomonas Infectionscystic fibrosisdiversitypersistent infectionPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID34160233
PMCPMC8265651
OpenAlexW3174671382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.