ArticleHead & neck2021
Respiratory-swallow coordination in a rat model of chemoradiation.
Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Oropharyngeal dysphagia and amyloid beta pathology in the TgF344-AD rat model of Alzheimer's disease.Frontiers in behavioral neuroscience · 2026Article
- Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics.Head & neck · 2025Article
- Bidirectional crosstalk between sleep disorders and gynecological cancers: unraveling molecular synergies and precision therapeutics.Frontiers in medicine · 2025Review
- Chemoradiation to the submental muscles alters hyoid movement during swallowing in a rat model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Swallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice.Laboratory animal research · 2024Article
- Article
- Pink1-/- Rats Demonstrate Swallowing and Gastrointestinal Dysfunction in a Model of Prodromal Parkinson Disease.Dysphagia · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundChemoradiation treatment (CRT) for head and neck cancer (HNC) is associated with postswallow inhale events that elevate the risk of penetration/aspiration. The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory-swallow coordination.
methodsVideofluoroscopic swallow study was performed on 10 Sprague-Dawley rats 3 months post-CRT (3 mg/kg Cisplatin, 10 fractions of 4.5 Gy/day radiotherapy to tongue base), and 10 naïve controls. We examined the effect of CRT on swallow apnea duration, diaphragm movement, and bolus kinematics.
resultsCRT rats had a significant increase in postswallow inhale (p = 0.008), which was associated with significantly longer swallow apnea durations, lower diaphragm displacement at swallow onset, and faster pharyngoesophageal bolus speed.
conclusionThe rat CRT model is valid for the study of respiratory-swallow coordination due to the consistency of findings in this study with those reported in clinical CRT studies in HNC.
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Registered trials
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