Evidence map›Paper›PMID 34160059›Full record

SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2021

Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.

Rahul K Gajbhiye, Mamta S Sawant, Periyasamy Kuppusamy, Suchitra Surve, Achhelal Pasi, Ranjan K Prusty, Smita D Mahale, Deepak N Modi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Pooled it
  4. Right-sizing Incentives.Journal of development economics · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rahul K GajbhiyeClinical Research Lab, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Mamta S SawantMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Periyasamy KuppusamyClinical Research Lab, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Suchitra SurveDepartment of Clinical Research, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Achhelal PasiAirport Health Organization, Ministry of Health and Family Welfare, Government of India, Mumbai, India.
Ranjan K PrustyDepartment of Biostatistics, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Smita D MahaleEmeritus Scientist, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Deepak N ModiMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.

Funding

DBT Wellcome India Alliance Clinical and Public Health Intermediate Fellowship IA/CPHI/18/1/503933DBT-Wellcome Trust India Alliance IA/CPHI/18/1/503933Indian Council of Medical Research (ICMR) ICMR-NIRRH RA/896/04-2020Wellcome Trust
6 · The paper itself

Abstract

backgroundSARS-CoV-2 has infected a large number of pregnant women.

objectiveTo compare clinical, perinatal outcomes of women with COVID-19 from high-income countries (HICs) and low- to middle-income countries (LMICs). SEARCH STRATEGY: Online databases were searched. SELECTION CRITERIA: Original studies on pregnant women with COVID-19 were included. DATA COLLECTION AND ANALYSIS: Information on clinical presentation, co-morbidities, pregnancy outcomes, neonatal outcomes, and SARS-CoV-2 infection in neonates was extracted. MAIN

resultsThe pooled estimate of SARS-CoV-2 positive neonates is 3.7%. Symptomatic presentations are less common in LMICs compared to HICs (odds ratio [OR] 0.38). Diabetes (OR 0.5), hypertension (OR 0.5), and asthma (OR 0.14) are commonly reported from HICs; hypothyroidism (OR 2.2), anemia (OR 3.2), and co-infections (OR 6.0) are commonly reported in LMICs. The overall risk of adverse pregnancy outcomes is higher in LMICs compared to HICs (OR 2.4). Abortion (OR 6.2), stillbirths (OR 2.0), and maternal death (OR 7.8) are more common in LMICs. Preterm births and premature rupture of membranes are comparable in both groups. Neonatal deaths (OR 3.7), pneumonia (OR 7.5), and neonatal SARS-CoV-2 infection (OR 1.8) are commonly reported in LMICs.

conclusionsIn LMICs, pregnant women and neonates are more vulnerable to adverse outcomes due to COVID-19. PROSPERO registration no: CRD42020198743.

Indexed as

COVID-19Pregnancy Complications, InfectiousPremature BirthDeveloped CountriesDeveloping CountriesFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy OutcomePregnant PeopleSARS-CoV-2coronavirusCOVID-19deathnewbornpregnancySARS-CoV-2stillbirthvertical transmission

Identifiers

PMID34160059
PMCPMC7612435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.