Evidence map›Paper›PMID 34160009›Full record

ArticleEuropean heart journal. Acute cardiovascular care2021

A-lines and B-lines in patients with acute heart failure.

Øyvind Johannessen, Brian Claggett, Eldrin F Lewis, John D Groarke, Varsha Swamy, Moritz Lindner, Scott D Solomon, Elke Platz

Open access · bronzeAbstract read
In one paragraph

Article in European heart journal. Acute cardiovascular care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
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  8. Observational
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Øyvind JohannessenFaculty of Medicine,Institute of Clinical Medicine, University of Oslo, Oslo 0316, Norway.ORCID 0000-0003-2632-7995
Brian ClaggettCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Eldrin F LewisCardiovascular Division, Stanford University, San Francisco, CA 94305, USA.
John D GroarkeCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Varsha SwamyCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Moritz LindnerFriedrich-Schiller-University, Jena 07737, Germany.
Scott D SolomonCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Elke PlatzCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-8604-0710
Brigham and Women's Hospital · USFriedrich Schiller University Jena · DEStanford University · USUniversity of Oslo · NO

Funding

Improving Pulmonary Congestion Assessment in Heart Failure with Preserved Ejection FractionR01HL148439 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2020 to 2024
$2.1M
Utility of Lung Ultrasound in Assessing Pulmonary Congestion in Heart FailureK23HL123533 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2015 to 2019
$881k
NHLBI NIH HHS K23 HL123533NHLBI NIH HHS R01 HL148439Norwegian Lung AssociationThe National Heart, Lung and Blood Institute K23HL123533
6 · The paper itself

Abstract

aimsLung ultrasound (LUS) relies on detecting artefacts, including A-lines and B-lines, when assessing dyspnoeic patients. A-lines are horizontal artefacts and characterize normal lung, whereas multiple vertical B-lines are associated with increased lung density. We sought to assess the prevalence of A-lines and B-lines in patients with acute heart failure (AHF) and examine their clinical correlates and their relationship with outcomes. METHODS AND

resultsIn a prospective cohort study of adults with AHF, eight-zone LUS and echocardiography were performed early during the hospitalization and pre-discharge at an imaging depth of 18 cm. A- and B-lines were analysed separately off-line, blinded to clinical and outcome data. Of 164 patients [median age 71 years, 61% men, mean ejection fraction (EF) 40%], the sum of A-lines at baseline ranged from 0 to 19 and B-line number from 0 to 36. One hundred and fifty-six patients (95%) had co-existing A-lines and B-lines at baseline. Lower body mass index and lower chest wall thickness were associated with a higher number of A-lines (P trend < 0.001 for both). In contrast to B-lines, there was no significant change in the number of A-lines from baseline to discharge (median 6 vs. 5, P = 0.80). While B-lines were associated with 90-day HF readmission or death, A-lines were not [HR 1.67, 95% confidence interval (CI) 1.11-2.51 vs. HR 0.97, 95% CI 0.65-1.43].

conclusionsA-lines and B-lines on LUS co-exist in the vast majority of hospitalized patients with AHF. In contrast to B-lines, A-lines were not associated with adverse outcomes.

Indexed as

Heart FailurePulmonary EdemaAdultAgedFemaleHumansLungMalePrognosisProspective StudiesUltrasonographyAcute heart failureA-linesB-linesLung ultrasoundPulmonary congestion

Identifiers

PMID34160009
PMCPMC8677442
OpenAlexW3174746905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.