Evidence map›Paper›PMID 34159880›Full record

ArticleGut microbes

A microbial signature following bariatric surgery is robustly consistent across multiple cohorts.

Farnaz Fouladi, Ian M Carroll, Thomas J Sharpton, Emily Bulik-Sullivan, Leslie Heinberg, Kristine J Steffen, Anthony A Fodor

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Abdominal Pain After Bariatric Surgery and the Role of the Gut: A Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A species ofFrontiers in endocrinology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farnaz FouladiDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, USA.ORCID 0000-0003-4369-8720
Ian M CarrollDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.ORCID 0000-0001-8615-5086
Thomas J SharptonDepartment of Microbiology, Department of Statistics, Center for Genome Research and Biocomputing, Oregon State University, Corvallis, USA.
Emily Bulik-SullivanDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.ORCID 0000-0002-3279-7240
Leslie HeinbergDepartment of Psychiatry and Psychology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, USA.
Kristine J SteffenSchool of Pharmacy, College of Health Professions, North Dakota State University, Fargo, USA.
Anthony A FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, USA.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Mechanisms that Predict Weight Trajectory after Bariatric Surgery: The Interactive Roles of Behavior and BiologyR01DK112585 · NIDDK · NORTH DAKOTA STATE UNIVERSITY · PI HEINBERG, LESLIE J., STEFFEN, KRISTINE JAYNE · 2016 to 2020
$4.5M
NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK112585
6 · The paper itself

Abstract

Bariatric surgery induces significant shifts in the gut microbiota which could potentially contribute to weight loss and metabolic benefits. The aim of this study was to characterize a microbial signature following Roux-en-Y Gastric bypass (RYGB) surgery using novel and existing gut microbiota sequence data. We generated 16S rRNA gene and metagenomic sequences from fecal samples from patients undergoing RYGB surgery (n = 61 for 16S rRNA gene and n = 135 for metagenomics) at pre-surgical baseline and one, six, and twelve-month post-surgery. We compared these data with three smaller publicly available 16S rRNA gene and one metagenomic datasets from patients who also underwent RYGB surgery. Linear mixed models and machine learning approaches were used to examine the presence of a common microbial signature across studies. Comparison of our new sequences with previous longitudinal studies revealed strikingly similar profiles in both fecal microbiota composition (r = 0.41 ± 0.10;

Indexed as

Gastrointestinal MicrobiomeAdultBacteriaBariatric SurgeryCohort StudiesDNA, BacterialFecesFemaleHumansLongitudinal StudiesMaleMetagenomicsMiddle AgedObesity, MorbidRNA, Ribosomal, 16SDNA, BacterialRNA, Ribosomal, 16Sgut microbiomeopportunistic pathogensRoux-en-Y gastric bypass surgery

Identifiers

PMID34159880
PMCPMC8224199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.