Evidence map›Paper›PMID 34159841›Full record

ArticleJournal of diabetes science and technology2021

Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia.

David C Klonoff, Jordan Messler, Timothy Valk, Ram Jagannathan, Francisco J Pasquel, Guillermo E Umpierrez

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David C KlonoffMills-Peninsula Medical Center, San Mateo, CA, USA.ORCID 0000-0001-6394-6862
Jordan MesslerGlytec, Waltham, MA, USA.ORCID 0000-0002-3080-6940
Timothy ValkAdmetsys Corporation, Research Division, Winter Park, FL, USA.ORCID 0000-0002-0345-4732
Ram JagannathanEmory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-4267-5033
Francisco J PasquelEmory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3845-6703
Guillermo E UmpierrezEmory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3252-5026
Emory University · USMills Peninsula Health Services · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery PatientsK23GM128221 · NIGMS · EMORY UNIVERSITY · PI PASQUEL, FRANCISCO J · 2018 to 2022
$957k
NCATS NIH HHS UL1 TR002378NIDDK NIH HHS P30 DK111024NIGMS NIH HHS K23 GM128221
6 · The paper itself

Abstract

Complications of Coronavirus Disease 2019 (COVID-19) occur with increased frequency in people admitted to the hospital with diabetes or hyperglycemia. The increased risk for COVID-19 infections in the presence of these metabolic conditions is in part due to overlapping pathophysiologic features of COVID-19, diabetes, and glucose control. Various antiviral treatments are being tested in COVID-19 patients. We believe that in these trials, it will be useful to evaluate treatment effect differences in patients stratified according to whether they have diabetes or hyperglycemia. In this way, it will be possible to better facilitate development of antiviral treatments that are most specifically beneficial for the large subset of COVID-19 patients who have diabetes or hyperglycemia.

Indexed as

Clinical Trials as TopicDiabetes MellitusHyperglycemiaAntiviral AgentsBlood GlucoseCOVID-19Data AccuracyHospitalizationHumansResearch DesignRisk FactorsSARS-CoV-2Antiviral AgentsBlood Glucoseantiviralclinical trialCOVID-19diabeteshospitalhyperglycemia

Identifiers

PMID34159841
PMCPMC8442178
OpenAlexW3177018526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.