Evidence map›Paper›PMID 34159808›Full record

ArticlePhysiology (Bethesda, Md.)2021

Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?

Heike Münzberg, Elizabeth Floyd, Ji Suk Chang

Open access · greenAbstract read
In one paragraph

Article in Physiology (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. G proteins of the GScience advances · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome.International journal of molecular sciences · 2023
    Review
  13. Article
  14. An American Physiological Society cross-journal Call for Papers on "The Physiology of Obesity".American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Heike MünzbergPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana.ORCID 0000-0002-1152-4884
Elizabeth FloydPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana.ORCID 0000-0002-3002-6186
Ji Suk ChangPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana.ORCID 0000-0002-0706-1960
Pennington Biomedical Research Center · US

Funding

Pregnane and Glycosides and Obesity/llya RaskinP50AT002776 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RASKIN, ILYA · 2005 to 2019
$24.9M
Leptin and Central Control of ThermoregulationR01DK092587 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2012 to 2024
$3.5M
Genetically-based neuro-modulation of adipose tissue functionsOT2OD023864 · OD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MUENZBERG-GRUENING, HEIKE · 2016 to 2019
$3.1M
The short isoform of PGC-1alpha in the control of brown adipose tissue thermogenesisR01DK104748 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CHANG, JI SUK · 2015 to 2019
$1.7M
NCCIH NIH HHS P50 AT002776NIDDK NIH HHS R01 DK092587NIDDK NIH HHS R01 DK104748NIH HHS OT2 OD023864
6 · The paper itself

Abstract

Obesity research progresses in understanding neuronal circuits and adipocyte biology to regulate metabolism. However, the interface of neuro-adipocyte interaction is less studied. We summarize the current knowledge of adipose tissue innervation and interaction with adipocytes and emphasize adipocyte transitions from white to brown adipocytes and vice versa. We further highlight emerging concepts for the differential neuronal regulation of brown/beige versus white adipocyte and the interdependence of both for metabolic regulation.

Indexed as

Adipocytes, BeigeThermogenesisAdipocytes, BrownAdipose TissueEnergy MetabolismHumansObesitydifferential innervationpreganglionicsympathetic chainthermogenesisvaricosities

Identifiers

PMID34159808
PMCPMC8424562
OpenAlexW3177058708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.