Evidence map›Paper›PMID 34159686›Full record

ArticleCancer science2021

Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis.

Yuanxin Tang, Taifang Wang, Yue Yu, Yuhao Yan, Chunli Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

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  13. Mechanism of Herb PairsEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuanxin TangDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Taifang WangDepartment of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yue YuDepartment of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Yuhao YanDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Chunli WuDepartment of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0003-1809-6752
Fourth Affiliated Hospital of China Medical University · CN

Funding

Young and middle-aged scientific and technological talents support program of Shenyang City RC200554
6 · The paper itself

Abstract

Clinical reports indicate that gastric cancer (GC) has a high mortality rate, but its pathological mechanism remains poorly understood. This work integrated bioinformatics analysis with experimental verification to explore novel biomarkers of gastric cancer. First, weighted gene coexpression network analysis was applied to screen significant genes correlated with GC development. Gene set enrichment analysis was also used to unearth the most relevant biological functions of significant genes. As a result, we discovered homeobox C9 (HOXC9) as a novel oncogene in GC, primarily through negatively regulating immune response. High expression of HOXC9 predicted a poor prognosis in GC patients, and knocking down HOXC9 efficiently enhanced the interferon-gamma (IFNγ)-dependent apoptosis in two GC cell lines as well as organoids from patients. Furthermore, cleaved caspase-3/7 and phosphorylated signal transducer and activator of transcription 1 (p-STAT1) were also significantly enhanced in HOXC9 knockdown cells and organoids treated with IFNγ. Mechanistically, we found that HOXC9 inhibited the death-associated protein kinase 1 (DAPK1) and its downstream retinoic acid-inducible gene-I (RIG1) to generate GC IFNγ resistance. In summary, we identified and confirmed that HOXC9 generates IFNγ resistance in GC by inhibiting the DAPK1/RIG1/p-STAT1 axis.

Indexed as

ApoptosisCell Line, TumorCell SurvivalCohort StudiesDatabases, GeneticDeath-Associated Protein KinasesDrug Resistance, NeoplasmGene Knockdown TechniquesHomeodomain ProteinsHumansImmune Checkpoint InhibitorsInterferon-gammaMelanomaOncogenesReceptors, Retinoic AcidSignal TransductionDAPK1 protein, humanDeath-Associated Protein KinasesHomeodomain ProteinsHoxc9 protein, humanImmune Checkpoint InhibitorsInterferon-gammaPLAAT4 protein, humanReceptors, Retinoic AcidSTAT1 protein, humanSTAT1 Transcription FactorDAPK1/RIG1/p-STAT1gastric cancerHOXC9IFNγ resistanceweighted coexpression network

Identifiers

PMID34159686
PMCPMC8409412
OpenAlexW3177229907

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.