ArticleRespirology (Carlton, Vic.)2021
COVID-19: Histopathological correlates of imaging patterns on chest computed tomography.
Article in Respirology (Carlton, Vic.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Cardio-Pulmonary Features of Long COVID: From Molecular and Histopathological Characteristics to Clinical Implications.International journal of molecular sciences · 2025Review
- Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook.Seminars in thrombosis and hemostasis · 2025Review
- Chest computed tomography and plain radiographs demonstrate vascular distribution and characteristics in COVID-19 lung disease - a pulmonary vasculopathy.The Ulster medical journal · 2025Article
- Nosocomial Bacterial Bronchopneumonia and SARS-CoV-2 Pneumonia in Patients with Traumatic Injuries: Imaging Aspects and Macroscopic and Microscopic Findings of Lung Tissue.Diagnostics (Basel, Switzerland) · 2024Article
- Comparison of clinical, laboratory and radiological characteristics between COVID-19 and Chlamydia psittaci pneumonia: a multicenter retrospective study.Scientific reports · 2024Article
- Mechanisms of Pulmonary Vasculopathy in Acute and Long-Term COVID-19: A Review.International journal of molecular sciences · 2024Review
- Prediction of oxygen supplementation by a deep-learning model integrating clinical parameters and chest CT images in COVID-19.Japanese journal of radiology · 2023Article
- Association of subpleural ground-glass opacities with respiratory failure and RNAemia in COVID-19.European radiology · 2023Observational
- Review
- Review
- Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery.The European respiratory journal · 2023Article
- Characteristic patterns of SARS-CoV-2 on chest CT suggests a hematologic pathway for viral entry into the lung.Clinical imaging · 2022Article
- Contemporary Concise Review 2021: COVID-19 and other respiratory infections.Respirology (Carlton, Vic.) · 2022Review
- Investigation of the relationship of CO-RADS and CT patterns with laboratory parameters in COVID-19 patients and a new perspective on the total CT scoring system.BMC medical imaging · 2022Article
- Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome.ERJ open research · 2022Article
- What Is COVID 19 Teaching Us about Pulmonary Ultrasound?Diagnostics (Basel, Switzerland) · 2022Review
- Pulmonary vascular involvement in COVID-19 pneumonitis: Is this the first and final insult?Respirology (Carlton, Vic.) · 2021Article
- COVID-19: Histopathological correlates of imaging patterns on chest computed tomography.Respirology (Carlton, Vic.) · 2021Article
- Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 Lungs.Frontiers in cardiovascular medicine · 2021Review
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15 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivePatients with coronavirus disease 2019 (COVID-19) pneumonia present with typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging findings to histopathological patterns, this study aimed to explain typical COVID-19 CT patterns at tissue level.
methodsEight autopsy cases were prospectively selected of patients with PCR-proven COVID-19 pneumonia with varying clinical manifestations and causes of death. All had been subjected to chest CT imaging 24-72 h prior to death. Twenty-seven lung areas with typical COVID-19 patterns and two radiologically unaffected pulmonary areas were correlated to histopathological findings in the same lung regions.
resultsTwo dominant radiological patterns were observed: ground-glass opacity (GGO) (n = 11) and consolidation (n = 16). In seven of 11 sampled areas of GGO, diffuse alveolar damage (DAD) was observed. In four areas of GGO, the histological pattern was vascular damage and thrombosis, with (n = 2) or without DAD (n = 2). DAD was also observed in five of 16 samples derived from areas of radiological consolidation. Seven areas of consolidation were based on a combination of DAD, vascular damage and thrombosis. In four areas of consolidation, bronchopneumonia was found. Unexpectedly, in samples from radiologically unaffected lung parenchyma, evidence was found of vascular damage and thrombosis.
conclusionIn COVID-19, radiological findings of GGO and consolidation are mostly explained by DAD or a combination of DAD and vascular damage plus thrombosis. However, the different typical CT patterns in COVID-19 are not related to specific histopathological patterns. Microvascular damage and thrombosis are even encountered in the radiologically normal lung.
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