Evidence map›Paper›PMID 34159621›Full record

ArticleThe EMBO journal2021

Prime time for the recycling endosome.

Brian P Ceresa

Open access · greenAbstract readComment
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Brian P CeresaDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-2310-6137
University of Louisville · US

Funding

Chemical Optimization of c-Cbl Antagonists for Corneal Wound HealingR01EY028911 · NEI · UNIVERSITY OF LOUISVILLE · PI CERESA, BRIAN P. · 2019 to 2023
$1.9M
NEI NIH HHS R01 EY028911
6 · The paper itself

Abstract

Receptor crosstalk is the phenomenon by which one cell surface receptor communicates with another to modulate its activity. In this issue, Smith et␣al (2021) demonstrate that such crosstalk may involve endocytic trafficking, as ligands promoting FGFR2b recycling induce a specific "priming" EGFR phosphorylation to direct unliganded EGFR to the recycling endosome, slow the lysosomal degradation of ligand-stimulated EGFR, and enhance signaling and cell proliferation.

Indexed as

EndosomesErbB ReceptorsLigandsPhosphorylationSignal TransductionErbB ReceptorsLigands

Identifiers

PMID34159621
PMCPMC8447598
OpenAlexW3175442390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.