SynthesisReviews in endocrine & metabolic disorders2022
A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward.
Synthesis in Reviews in endocrine & metabolic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.Schizophrenia bulletin · 2024Trial
- Trial
- Large-Scale Brain Network Connectivity Mediates the Association Between Metabolic Risk Factors and Cognition: An fMRI Study of the Human Connectome Project.International journal of endocrinology and metabolism · 2026Article
- Brain functional connectivity patterns associated with adiposity in schizophrenia.Psychiatry research. Neuroimaging · 2026Article
- Interaction of physical activity and gut-brain axis: relevance for obesity.Reviews in endocrine & metabolic disorders · 2026Review
- Body mass index affects EEG microstate dynamics through blood viscosity in high-altitude environments.Frontiers in neuroscience · 2026Article
- Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.Life (Basel, Switzerland) · 2025Review
- Reward responses to vicarious feeding depend on body mass index.Cognitive, affective & behavioral neuroscience · 2025Article
- Exploring the link between inflammation and brain function after metabolic-bariatric surgery: A year-long fMRI study.Diabetes, obesity & metabolism · 2025Article
- Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.Obesity (Silver Spring, Md.) · 2025Article
- Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.Frontiers in nutrition · 2025Article
- Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.International journal of obesity (2005) · 2024Article
- Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia.Schizophrenia research · 2024Article
- White adipose tissue distribution and amount are associated with increased white matter connectivity.Human brain mapping · 2024Article
- Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.Research square · 2024Article
- Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Dynamic fronto-amygdalar interactions underlying emotion-regulation deficits in women at higher weight.Obesity (Silver Spring, Md.) · 2023Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Near-Infrared Spectroscopy: A Free-Living Neuroscience Tool to Better Understand Diabetes and Obesity.Metabolites · 2023Review
- Resting-state network functional connectivity before and after bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is the second most common cause of preventable morbidity worldwide. Resting-state functional magnetic resonance imaging (fMRI) has been used extensively to characterise altered communication between brain regions in individuals with obesity, though findings from this research have not yet been systematically evaluated within the context of prominent neurobiological frameworks. This systematic review aggregated resting-state fMRI findings in individuals with obesity and evaluated the contribution of these findings to current neurobiological models. Findings were considered in relation to a triadic model of problematic eating, outlining disrupted communication between reward, inhibitory, and homeostatic systems. We identified a pattern of consistently increased orbitofrontal and decreased insula cortex resting-state functional connectivity in individuals with obesity in comparison to healthy weight controls. BOLD signal amplitude was also increased in people with obesity across studies, predominantly confined to subcortical regions, including the hippocampus, amygdala, and putamen. We posit that altered orbitofrontal cortex connectivity may be indicative of a shift in the valuation of food-based rewards and that dysfunctional insula connectivity likely contributes to altered homeostatic signal processing. Homeostatic violation signals in obesity may be maintained despite satiety, thereby 'hijacking' the executive system and promoting further food intake. Moving forward, we provide a roadmap for more reliable resting-state and task-based functional connectivity experiments, which must be reconciled within a common framework if we are to uncover the interplay between psychological and biological factors within current theoretical frameworks.
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