Evidence map›Paper›PMID 34159494›Full record

ReviewClinical rheumatology2021

Use of ultrasound to diagnose and monitor interstitial lung disease in rheumatic diseases.

Esther F Vicente-Rabaneda, David A Bong, Santos Castañeda, Ingrid Möller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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  5. Pulmonary Involvement in Autoimmune-Mediated Disease.Deutsches Arzteblatt international · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Esther F Vicente-RabanedaRheumatology Department, Hospital Universitario de La Princesa, IIS-Princesa. C/ Diego de León 62, 28006, Madrid, Spain. efvicenter@gmail.com.ORCID http://orcid.org/0000-0001-6823-4194
David A BongFaculty of Medicine, University of Barcelona-Bellvitge Campus, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6691-7968
Santos CastañedaRheumatology Department, Hospital Universitario de La Princesa, IIS-Princesa. C/ Diego de León 62, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-7748-853X
Ingrid MöllerInstituto Poal de Reumatología Barcelona, EULAR Working Group Anatomy for the Image, University of Barcelona, International University of Catalunya, Castanyer 15, Sarrià-Sant Gervasi 08022, Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9225-2568
Hospital Universitario de La Princesa · ESUniversitat de Barcelona · ESUniversitat Internacional de Catalunya · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial lung disease (ILD) is one of the most relevant extra-articular manifestations of rheumatic diseases resulting in a substantial increase in morbidity and mortality. Early diagnosis and close monitoring to identify patients at high risk of progression are crucial to establish the need for targeted treatment with immunomodulatory and antifibrotic drugs, with potential ability to change the course of the disease. However, there are unmet needs in this field as pulmonary auscultation, chest radiography, or pulmonary function studies do not allow identification of the most incipient stages of the disease. High-resolution computed tomography (HRCT), which is the current gold standard for diagnosis and evolutionary control, is problematic owing to ionizing radiation, cost, and accessibility. In this context, lung ultrasound (LUS) is an attractive tool in a growing research and validation process. The identification of vertical artifacts, such as B lines, and alterations of the pleural line present a good correlation with the presence of ILD by HRCT and have a good concordance with the extent and severity of the disease, with sensitivity and negative predictive values of up to 100%. Regarding the monitoring of the evolution, the validation process of LUS is in a more preliminary phase but data is encouraging. All this, together with its safety, accessibility, low cost, and good patient acceptance, postulate LUS as a useful tool for the screening of ILD and for the optimization of the indications of HRCT. Key Points • The good sensitivity and negative predictive values of LUS postulate this technique as a useful tool for the screening of ILD and for the optimization of the indications of HRCT in rheumatic diseases.

Indexed as

Lung Diseases, InterstitialRheumatic DiseasesHumansLungTomography, X-Ray ComputedUltrasonographyInflammatory myopathiesInterstitial lung diseaseLung ultrasoundRheumatic diseasesRheumatoid arthritisSystemic sclerosis

Identifiers

PMID34159494
OpenAlexW3174410624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.