Evidence map›Paper›PMID 34159460›Full record

Trial reportSurgical endoscopy2022

Pre-administration of super-low volume polyethylene glycol is as effective as senna laxative as bowel preparation for colonoscopy: a randomized controlled phase 2 trial.

Fumiaki Ishibashi, Ryu Tanaka, Kazuaki Sugihara, Kenichi Konda, Ayako Sato, Tomohiro Kawakami, Konomi Kobayashi, Satoshi Baba

Abstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. An algorithm-based active cleansing protocol can reduce the bowel preparation time for screening colonoscopy: A propensity score matching study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
    Article
  3. Dietary restriction after cold snare polypectomy of colorectal polyp for prevention of delayed bleeding.JGH open : an open access journal of gastroenterology and hepatology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fumiaki IshibashiEndoscopy Center, Koganei Tsurukame Clinic, 6-14-28-3F, Honcho, Koganei-shi, Tokyo, 184-0004, Japan. ishibashi@tsurukamekai.jp.ORCID 0000-0003-4065-7958
Ryu TanakaDigestive Disease Center, Shinjuku Tsurukame Clinic, 2-11-15, Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Kazuaki SugiharaDigestive Disease Center, Shinjuku Tsurukame Clinic, 2-11-15, Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Kenichi KondaDigestive Disease Center, Shinjuku Tsurukame Clinic, 2-11-15, Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Ayako SatoDigestive Disease Center, Shinjuku Tsurukame Clinic, 2-11-15, Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Tomohiro KawakamiEndoscopy Center, Koganei Tsurukame Clinic, 6-14-28-3F, Honcho, Koganei-shi, Tokyo, 184-0004, Japan.
Konomi KobayashiEndoscopy Center, Koganei Tsurukame Clinic, 6-14-28-3F, Honcho, Koganei-shi, Tokyo, 184-0004, Japan.
Satoshi BabaDigestive Disease Center, Shinjuku Tsurukame Clinic, 2-11-15, Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan.
Tokyo Medical and Dental University · JPShowa University · JPYotsuya Medical Cube · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSenna laxatives are commonly used for bowel preparation before colonoscopies in Japan. However, this laxative frequently causes complications such as abdominal pain. This study aimed to establish a novel method of bowel preparation, which involved the pre-administration of super-low volume polyethylene glycol (PEG) for three days followed by the same-day administration of low volume PEG.

methodsThis study was a prospective, multicenter, investigator-blinded, phase 2, randomized control trial. The intake of 13.9 g (120 mL) of PEG or 1 g of a senna laxative for 3 days before the examination was indicated for each group, and 2 L of PEG solution was used for preparation on the examination day. The primary endpoint was the efficacy of bowel cleansing, as assessed by the Boston bowel preparation scale. The secondary endpoints were the adenoma detection rate and occurrence of complications.

resultsA total of 250 patients were initially enrolled. A total of 122 patients from each group were included in the intention-to-treat analysis. In the intention-to-treat analysis, the responder rates were the same for the two groups (56.6% vs 50.8%). Additionally, the adenoma detection rate did not differ between the two groups (34.9% vs 41.8%, P = 0.3795). In contrast, adherence was higher in the PEG group (93.4% vs 82.8%, P = 0.0101), and the occurrence of complications was lower in the PEG group (1.7% vs 16.4%, P = 0.0001).

conclusionThe novel super-low volume PEG method for bowel preparation was as effective as the conventional method with senna laxatives.

Indexed as

AdenomaLaxativesCatharticsColonoscopyHumansPolyethylene GlycolsProspective StudiesCatharticsLaxativesPolyethylene GlycolsAdenomaColonoscopyPolyethylene glycolsSennosides

Identifiers

PMID34159460
OpenAlexW3176957106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.