Trial reportThe American journal of clinical nutrition2021
Effect of 2-year caloric restriction on organ and tissue size in nonobese 21- to 50-year-old adults in a randomized clinical trial: the CALERIE study.
Trial report in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02695511 (CALERIE Phase II Ancillary 2), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CALERIE Phase II Ancillary 2: Metabolic Adaptation After Two Years of Caloric Restriction in Non Obese Humans
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of caloric restriction on organ size and its contribution to metabolic adaptation: an ancillary analysis of CALERIE 2.Scientific reports · 2025Trial
- The CALERIE Genomic Data Resource.Nature aging · 2025Trial
- Visceral Fat-Reducing Effect of Novel Dietary Intervention Program: A Randomized Controlled Trial in Japanese Males.Nutrients · 2024Trial
- Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.Aging cell · 2023Trial
- Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.Nature aging · 2023Trial
- Longitudinal Deterioration in Nutritional Status Associated With Increased Risk of Sarcopenia in Community-Dwelling Aged Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Understanding Impact of Anti-Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- Treadmill training or caloric restriction delays aging-associated increase in urocortin 2-induced hyperthermia in middle-aged male Wistar rats.Scientific reports · 2025Article
- Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?Antioxidants (Basel, Switzerland) · 2025Review
- Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.Obesity (Silver Spring, Md.) · 2024Article
- The pathophysiology of visceral adipose tissues in cardiometabolic diseases.Biochemical pharmacology · 2024Review
- The heat of longevity: sex differences in lifespan and body temperature.Frontiers in pharmacology · 2024Article
- Proportion of caloric restriction-induced weight loss as skeletal muscle.Obesity (Silver Spring, Md.) · 2024Article
- The Future is Now - Emerging Trends in the Older Adult.Journal of human nutrition and food science · 2024Article
- Intermuscular adipose tissue in metabolic disease.Nature reviews. Endocrinology · 2023Review
- Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia.Cells · 2023Review
- Research progress of AMP-activated protein kinase and cardiac aging.Open life sciences · 2023Review
- PLA2G7: a new player in shaping energy metabolism and lifespan.Signal transduction and targeted therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSustained calorie restriction (CR) promises to extend the lifespan. The effect of CR on changes in body mass across tissues and organs is unclear.
objectivesWe used whole-body MRI to evaluate the effect of 2 y of CR on changes in body composition.
methodsIn an ancillary study of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, 43 healthy adults [25-50 y; BMI (kg/m2): 22-28] randomly assigned to 25% CR (n = 28) or ad libitum (AL) eating (n = 15) underwent whole-body MRI at baseline and month 24 to measure adipose tissue in subcutaneous, visceral, and intermuscular depots (SAT, VAT, and IMAT, respectively); skeletal muscle; and organs including brain, liver, spleen, and kidneys but not heart.
resultsThe CR group lost more adipose tissue and lean tissue than controls (P < 0.05). In the CR group, at baseline, total tissue volume comprised 32.1%, 1.9%, and 1.0% of SAT, VAT, and IMAT, respectively. The loss of total tissue volume over 24 mo comprised 68.4%, 7.4%, and 2.2% of SAT, VAT, and IMAT, respectively, demonstrating preferential loss of fat vs. lean tissue. Although there is more muscle loss in CR than AL (P < 0.05), the loss of muscle over 24 mo in the CR group comprised only 17.2% of the loss of total tissue volume. Changes in organ volumes were not different between CR and AL. The degree of CR (% decrease in energy intake vs. baseline) significantly (P < 0.05) affected changes in VAT, IMAT, muscle, and liver volume (standardized regression coefficient ± standard error of estimates: 0.43 ± 0.15 L, 0.40 ± 0.19 L, 0.55 ± 0.17 L, and 0.45 ± 0.18 L, respectively).
conclusionsTwenty-four months of CR (intended, 25%; actual, 13.7%) in young individuals without obesity had effects on body composition, including a preferential loss of adipose tissue, especially VAT, over the loss of muscle and organ tissue. This trial was registered at www.clinicaltrials.gov as NCT02695511.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.