Evidence map›Paper›PMID 34159332›Full record

ArticlebioRxiv : the preprint server for biology2021

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates.

K Rosenke, F Feldmann, A Okumura, F Hansen, T Tang-Huau, K Meade-White, B Kaza, B J Smith, P W Hanley, J Lovaglio and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

K RosenkeLaboratory of Virology, Hamilton, MT, Unites States.
F FeldmannRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States.
A OkumuraLaboratory of Virology, Hamilton, MT, Unites States.
F HansenLaboratory of Virology, Hamilton, MT, Unites States.
T Tang-HuauLaboratory of Virology, Hamilton, MT, Unites States.
K Meade-WhiteLaboratory of Virology, Hamilton, MT, Unites States.
B KazaLaboratory of Virology, Hamilton, MT, Unites States.
B J SmithRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States.
P W HanleyRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States.
J LovaglioRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States.
M A JarvisLaboratory of Virology, Hamilton, MT, Unites States.
C ShaiaRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Hamilton, MT, Unites States.
H FeldmannLaboratory of Virology, Hamilton, MT, Unites States.
National Institutes of Health · USPlymouth City Council · GB

Funding

Veterinary Services Core for Infectious Diseases Research- RMLZIGAI001048 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HANLEY, PATRICK · 2009 to 2025
$135.0M
SARS-CoV-2: Pathogenesis and Countermeasure DevelopmentZIAAI001300 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FELDMANN, HEINRICH · 2020 to 2023
$3.3M
Animal Research Support of COVID StudiesZICAI001330 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HANLEY, PATRICK · 2020 to 2022
$3.2M
6 · The paper itself

Abstract

The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, African green monkeys were infected intranasally with either a contemporary D614G or the UK B.1.1.7 variant. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tract tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases. ONE-SENTENCE SUMMARY: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.

Identifiers

PMID34159332
PMCPMC8219096
OpenAlexW3171163292

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.