ArticleJournal of the Endocrine Society2021
Pregnancy-specific Reference Intervals for BNP and NT-pro BNP-Changes in Natriuretic Peptides Related to Pregnancy.
Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Pre-Eclampsia and Maternal Cardiovascular Function: Insights Into Pathophysiology and Care (Scientific Impact Paper No. 79).BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Cardiac Biomarkers and Pregnancy-Associated Cardiovascular Disease.Current cardiology reports · 2026Review
- BNP-Derived Uric Acid Composite Indices for the Evaluation of Dyspnea in Third-Trimester Pregnancy: A Prospective Emergency Department Study.Journal of clinical medicine · 2026Article
- NT-proBNP as a Predictive and Prognostic Biomarker for Complications in Hypertensive Pregnancy Disorders.Journal of clinical medicine · 2026Article
- Cardiac Biomarkers in Pregnancies With and Without Hypertension.American journal of hypertension · 2025Article
- Maternal heart failure: state-of-the-art review.Heart failure reviews · 2025Review
- Cardio-obstetrics in the Cardiac Intensive Care Unit: An Introductory Guide.US cardiology · 2025Review
- High Serum Adrenomedullin and Mid-Regional Pro-Atrial Natriuretic Peptide Concentrations in Early Pregnancy Predict the Development of Gestational Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- Comparative analysis of COVID-19 pneumonia in pregnant versus matched non-pregnant women: radiologic, laboratory, and clinical perspectives.Scientific reports · 2024Article
- Biomarkers in Peripartum Cardiomyopathy-What We Know and What Is Still to Be Found.Biomolecules · 2024Review
- A 20-year population study of peripartum cardiomyopathy.European heart journal · 2023Article
- Anaesthesia and peripartum cardiomyopathy.BJA education · 2023Review
- Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population.JACC. Advances · 2023Article
- Dynamics of NT-proBNP in Pregnancy: Why Values May Be Elevated in the First Trimester.JACC. Advances · 2023Article
- Obstetric Disorders and Critical Illness.Clinics in chest medicine · 2022Review
- The Utilization and Interpretation of Cardiac Biomarkers During Pregnancy:JACC. Advances · 2022Review
- Serum miR-204 and miR-451 Expression and Diagnostic Value in Patients with Pulmonary Artery Hypertension Triggered by Congenital Heart Disease.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCardiac disease is the leading cause of maternal mortality in the UK, so accurate cardiovascular diagnoses in pregnancy are essential. BNP (B-type natriuretic peptide) and NT-pro BNP (N-terminal-pro BNP) are useful clinical tools for investigating suspected peripartum cardiomyopathy but, as the pregnancy-specific reference intervals are undefined, it is uncertain how they should be interpreted in pregnant women.
objectivesTo define trimester-specific 95% reference intervals for BNP and NT-pro BNP in pregnancy.
methodsLongitudinal study of 260 healthy pregnant women, with sampling in each trimester.
resultsThe upper reference limit for NT-pro BNP was 200 pg/mL in the first and second trimesters, and 150 pg/mL in the third. Levels were significantly reduced in overweight women in the third trimester (
conclusionCardiac biomarkers have an important role for investigating suspected disease in high-risk pregnant women, but a robust assessment of the levels expected in healthy pregnant women is an essential prerequisite to their application in clinical practice. This study has defined trimester- and BMI-specific reference intervals for NT-pro BNP and BNP, which may improve how women with suspected cardiovascular disease are investigated in pregnancy.
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