Evidence map›Paper›PMID 34159132›Full record

ArticleInternational journal of critical illness and injury science

Impact of blood alcohol concentration on hematologic and serum chemistry parameters in trauma patients: Analysis of data from a high-volume level 1 trauma center.

Kathryn Clare Kelley, Philip Salen, Thomas R Wojda, Aliaskar Z Hasani, Joshua Luster, Jacqueline Seoane, Marissa Zwiebel Cohen, Roberto Castillo, Stanislaw P Stawicki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of critical illness and injury science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kathryn Clare KelleyDepartment of Surgery, University Campus, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.
Philip SalenDepartment of Emergency Medicine, University Campus, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.
Thomas R WojdaDepartment of Family Medicine, Warren Campus, St. Luke's University Health Network, Phillipsburg, New Jersey, USA.
Aliaskar Z HasaniDepartment of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Joshua LusterDepartment of Neurology, San Antonio Military Medical Center, San Antonio, Texas, USA.
Jacqueline SeoaneDepartment of Surgery, Orlando Health, Orlando, Florida, USA.
Marissa Zwiebel CohenDepartment of Emergency Medicine, University Campus, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.
Roberto CastilloDepartment of Surgery, University Campus, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.
Stanislaw P StawickiDepartment of Surgery, University Campus, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.
St. Luke's University Health Network · USMontefiore Medical Center · USOrlando Health · USSan Antonio Military Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol (EtOH) intoxication is common among trauma patients. While providers are familiar with the clinical aspects of acute EtOH intoxication, few studies have investigated the effects that EtOH levels may have on common laboratory markers. The aim of this study was to identify hematologic and serum chemistry parameters that may be affected by the blood alcohol concentration (BAC), hypothesizing that BAC influences both comprehensive blood count (CBC) and comprehensive serum chemistry (CSC) components.

methodsWe performed an IRB-exempt institutional registry review of all trauma patients who had serum EtOH levels measured between January 2009 and June 2015. Data for each patient included: patient demographics, BAC determinations (g/dL), injury mechanism/severity information (ISS), hematologic parameters included in a CBC (hemoglobin, hematocrit, white blood cell [WBC] count, and platelet count), and CSC panel components (sodium, potassium, chloride, bicarbonate, blood urea nitrogen [BUN], creatinine, glucose, and hepatic function tests). Laboratory markers were contrasted across predefined categories of BAC: <0.10%, 10%-15%, 15%-20%, and >20%. Statistical comparisons were performed using SPSS 18 Software, employing analysis-of-covariance with adjustments performed for the patient demographics and injury characteristics. Statistical significance was set at α = 0.005.

resultsA total of 2167 patient records were analyzed. After adjusting for patient age, gender, and ISS, increasing BAC correlated with 4.8% increase in hemoglobin and 32.5% higher hematocrit (both

conclusionDue to the paucity of literature relating to the effects of BAC on serum hematologic and biochemical markers in acute trauma, this study provides a foundation for further exploration of these relationships and their clinical impact. More specifically, we found that BAC levels significantly influenced key laboratory markers, suggesting that acute EtOH intoxication may lead to hematologic and CSC changes that are potentially important in acute trauma management by frontline clinical staff.

Indexed as

Alcohol intoxicationhematologyinjurylaboratory valuesserum chemistrytrauma

Identifiers

PMID34159132
PMCPMC8183372
OpenAlexW3152061614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.