Evidence map›Paper›PMID 34159062›Full record

ArticlePublic health action2021

Laboratory comparison of stool processing methods for Xpert

C L Jasumback, Q Dlamini, J Kahari, G Maphalala, M G Dlamini, G S Dube, A DiNardo, H L Kirchner, A Mandalakas, A W Kay

Open access · diamondAbstract read
In one paragraph

Article in Public health action, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Use of stool swabs in molecular transport media increases access to Xpert Ultra testing for TB in children.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
  8. Article
  9. Pediatric Tuberculosis Diagnostics: Present and Future.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

C L JasumbackUnited States Peace Corps, Mbabane, Eswatini.
Q DlaminiBaylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini.
J KahariBaylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini.
G MaphalalaEswatini National Health Services Laboratory, Mbabane, Eswatini.
M G DlaminiEswatini National Health Services Laboratory, Mbabane, Eswatini.
G S DubeEswatini National Tuberculosis Control Program, Manzini, Eswatini.
A DiNardoBaylor College of Medicine, Houston, TX, USA.
H L KirchnerDepartment of Population Health Sciences, Geisinger, Danville, VA, USA.
A MandalakasBaylor College of Medicine, Houston, TX, USA.
A W KayBaylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini.
Baylor College of Medicine · USGeisinger Health System · USPeace Corps · USSouthern Africa Nazarene University · SZ

Funding

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment MonitoringR01AI137527 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MANDALAKAS, ANNA M · 2019 to 2022
$2.7M
Developing Clinical Prediction Tools to Define Strategies for Differentiated Service Delivery in Children and Adolescents Living with HIV in sub-Saharan Africa.K01TW011482 · FIC · BAYLOR COLLEGE OF MEDICINE · PI KAY, ALEXANDER WILLIAM · 2020 to 2024
$749k
FIC NIH HHS K01 TW011482NIAID NIH HHS R01 AI137527
6 · The paper itself

Abstract

TB disease diagnosis in children is difficult due to non-specific symptoms, paucibacillary disease and the need for invasive procedures to obtain diagnostic specimens. In many settings, these specimens are simply not collected and therefore stool, easily obtained, has emerged as a promising specimen for the diagnosis of child TB. In this study, stool from a healthy adult was spiked with known concentrations of bacille Calmette-Guérin vaccine and tested using the Xpert

Indexed as

childdiagnosistuberculosis

Identifiers

PMID34159062
PMCPMC8202631
OpenAlexW3166591435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.