Evidence map›Paper›PMID 34158867›Full record

ArticleTheranostics2021

Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment.

Ann-Christin Frank, Rebecca Raue, Dominik C Fuhrmann, Evelyn Sirait-Fischer, Carsten Reuse, Andreas Weigert, Dieter Lütjohann, Karsten Hiller, Shahzad Nawaz Syed, Bernhard Brüne

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. The moonlighting functions of glycolytic enzymes in tumorigenesis.Cellular oncology (Dordrecht, Netherlands) · 2026
    Review
  6. Review
  7. The new insights of lactate in various kidney diseases.Expert reviews in molecular medicine · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Lactate and lactylation in cancer.Signal transduction and targeted therapy · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ann-Christin FrankInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Rebecca RaueInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Dominik C FuhrmannInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Evelyn Sirait-FischerInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Carsten ReuseDepartment for Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany.
Andreas WeigertInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Dieter LütjohannInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
Karsten HillerDepartment for Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany.
Shahzad Nawaz SyedInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Bernhard BrüneInstitute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Goethe University Frankfurt · DEFrankfurt Cancer Institute · DEHelmholtz Centre for Infection Research · DETechnische Universität Braunschweig · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Tumor MicroenvironmentAnimalsBreast NeoplasmsFemaleHumansIsoenzymesL-Lactate DehydrogenaseMacrophagesMammary Neoplasms, AnimalMCF-7 CellsIsoenzymeslactate dehydrogenase 1L-Lactate DehydrogenaseBreast cancerLDHBmetabolismRNA therapeuticstumor-associated macrophages.

Identifiers

PMID34158867
PMCPMC8210612
OpenAlexW3177357476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.