Evidence map›Paper›PMID 34158864›Full record

ArticleTheranostics2021

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.

Jiaxin Chen, Yizheng Wu, Xin Luo, Dongai Jin, Wei Zhou, Zhenyu Ju, Di Wang, Qing Meng, Huijuan Wang, Xiaotian Fu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 1 synthesis or guideline pooled it, 207 citations in OpenAlex.

  1. Pooled it
  2. [Metformin Inhibits Prostate Cancer Progression via Regulation of the AKT/mTOR Signaling Pathway].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jiaxin ChenDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Yizheng WuDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Xin LuoDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Dongai JinDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Wei ZhouDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Zhenyu JuKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, 510632 Guangzhou, China.
Di WangDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Qing MengDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Huijuan WangDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Xiaotian FuDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Jianbin XuDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Zhangfa SongDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China.
Regenerative Medicine Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RNA StabilityColorectal NeoplasmsELAV-Like Protein 1HCT116 CellsHeterogeneous-Nuclear RibonucleoproteinsHT29 CellsHumansNeoplasm MetastasisNeoplasm ProteinsPolypyrimidine Tract-Binding ProteinRNA, CircularRNA, MessengerRNA, NeoplasmELAVL1 protein, humanELAV-Like Protein 1Heterogeneous-Nuclear RibonucleoproteinsNeoplasm ProteinsPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanRNA, CircularRNA, MessengerRNA, NeoplasmADARB2cancer metastasiscircRHOBTB3colorectal cancerFUSHuRPTBP1

Identifiers

PMID34158864
PMCPMC8210600
OpenAlexW3169342439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.