Evidence map›Paper›PMID 34158849›Full record

ArticleTheranostics2021

Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver.

Yongjie Zhou, Hongjie Ji, Qing Xu, Xiaoyun Zhang, Xiaoyue Cao, Yuwei Chen, Mingyang Shao, Zhenru Wu, Jie Zhang, Changli Lu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026
    Review
  8. Antioxidants (Basel, Switzerland) · 2025
    Article
  9. Organoids in biliary atresia.World journal of pediatric surgery · 2025
    Review
  10. Genetic background and biliary atresia.World journal of pediatric surgery · 2025
    Review
  11. Article
  12. Article
  13. A modular analysis of bile canalicular function and its implications for cholestasis.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yongjie ZhouLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Hongjie JiSchool of Bioscience and Technology, Weifang Medical University, Weifang 261042, China.
Qing XuLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaoyun ZhangDepartment of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaoyue CaoLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Yuwei ChenLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Mingyang ShaoLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhenru WuLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Jie ZhangCore Facility of West China Hospital, Sichuan University, Chengdu 610041, China.
Changli LuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Jiayin YangDepartment of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Yujun ShiLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Hong BuLaboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNWest China Hospital of Sichuan University · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biliary AtresiaGenetic Diseases, InbornIntercellular JunctionsAnimalscdc42 GTP-Binding ProteinFemaleHumansInfantLiverMaleMiceMice, Knockoutcdc42 GTP-Binding ProteinCDC42 protein, humanCdc42 protein, mousebile acidsbiliary atresiaCdc42cell polarityepithelial junction

Identifiers

PMID34158849
PMCPMC8210598
OpenAlexW3168507206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.