ReviewNutrition and metabolic insights2021
Protein Intake and Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis.
Review in Nutrition and metabolic insights, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Review
- Unlocking the Functional Properties of Plant Proteins in Designing Food Formulations for Senior Adults.Comprehensive reviews in food science and food safety · 2026Review
- Effects of non-denatured whey protein supplementation combined with a Mediterranean-type diet on cognitive function and muscle health in sarcopenic older adults with cognitive impairment: a retrospective observational study.Frontiers in nutrition · 2026Article
- Adherence to the EAT-Lancet diet and change in cognitive functioning in older adults.European journal of nutrition · 2025Article
- Article
- Dietary Factors and Cognitive Function: with a Focus on Subjective Cognitive Decline.Current nutrition reports · 2025Review
- Effects of Protein Intake on Cognitive Function in Chinese Older Adults: A 10-Year Follow-Up Study.Nutrients · 2025Article
- Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health.Frontiers in molecular biosciences · 2025Review
- Yeast protein modulates metabolites derived from the human gut microbiota of older male adultsFrontiers in microbiology · 2025Article
- Dietary protein intake in midlife in relation to healthy aging - results from the prospective Nurses' Health Study cohort.The American journal of clinical nutrition · 2024Article
- Meat-egg-dairy consumption and depressive symptoms among Chinese older adults: exploring rural/urban and gender disparities.Frontiers in psychiatry · 2024Article
- The Dietary Carbohydrate/Fat-Ratio and Cognitive Performance: Panel Analyses in Older Adults at Risk for Dementia.Current developments in nutrition · 2023Article
- Review
- Nutrition and cognitive health: A life course approach.Frontiers in public health · 2023Review
- Association between Changes in Protein Intake and Risk of Cognitive Impairment: A Prospective Cohort Study.Nutrients · 2022Article
- The importance of midlife diet in late life cognitive outcomes.The American journal of clinical nutrition · 2022Article
- The moderating effect of dietary fiber and protein on the relationship between symptoms of depression and anxiety and cognitive decline.Alzheimer's & dementia (New York, N. Y.)Article
- The association of dietary protein intake in three meals and cognitive performance among people over sixty years old.Journal of Alzheimer's disease reportsArticle
- Macronutrient energy ratios and cognitive health in older adults: A binational study of nonlinear associations and mortality links.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe present study investigated the association between protein intake and cognitive function in older adults.
methodsWe performed a literature search with no restriction on publication year in MEDLINE, SCOPUS, CINAHL, AgeLine from inception up to October 2020. Observational studies that investigated as a primary or secondary outcome the association of protein intake and cognitive function in older adults aged ⩾60 years were included.
resultsNine cross-sectional studies that investigated a total of 4929 older adults were included in the qualitative analysis. Overall cognitive function was examined in 6 studies. Four investigations reported null associations and 2 studies found that older adults with a high protein intake had higher global cognitive function than their counterparts. Results from the meta-analysis suggested that there were no significant associations between protein consumption and global cognitive function in older adults, regardless of gender. Three studies investigated other cognitive domains. Memory and protein intake were significantly and positively correlated in all studies. In addition, visuospatial, verbal fluency, processing speed, and sustained attention were positively associated with protein consumption in 1 study each.
conclusionNo significant associations between protein intake and global cognitive function were observed in neither qualitative nor quantitative analyses. The association between protein consumption with multiple other cognitive domains were also tested. As a whole, 3 studies reported a positive and significant association between high protein intake and memory, while 1 study observed a significant and positive association with visuospatial, verbal fluency, processing speed, and sustained attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.