Evidence map›Paper›PMID 34158658›Full record

ReviewNature reviews. Urology2021

Exercise-induced myokines and their effect on prostate cancer.

Jin-Soo Kim, Daniel A Galvão, Robert U Newton, Elin Gray, Dennis R Taaffe

Erratum issued Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07048847 (The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy), which is not on this map. Cited by 74 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 6 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07048847 completednot on this mapstarted 2022, after this paper: background citation

The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy

TypeobservationalSponsorIzmir Bakircay UniversityRan2022 to 2023Enrolled32ConditionsBreast Cancer, Colon Cancer, Chemotherapy EffectArmsExercise
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. The effect of aerobic exercise on tumour blood delivery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  6. Pooled it
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  17. Exercise-myokine relationships in osteoarthritis.Journal of translational medicine · 2026
    Review
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  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jin-Soo KimExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. d.galvao@ecu.edu.au.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0003-0302-6129
Elin GraySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0002-8613-3570
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Edith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise is recognized by clinicians in the field of clinical oncology for its potential role in reducing the risk of certain cancers and in reducing the risk of disease recurrence and progression; yet, the underlying mechanisms behind this reduction in risk are not fully understood. Studies applying post-exercise blood serum directly to various types of cancer cell lines provide insight that exercise might have a role in inhibiting cancer growth via altered soluble and cell-free blood contents. Myokines, which are cytokines produced by muscle and secreted into the bloodstream, might offer multiple benefits to cellular metabolism (such as a reduction in insulin resistance, improved glucose uptake and reduced adiposity), and blood myokine levels can be altered with exercise. Alterations in the levels of myokines such as IL-6, IL-15, IL-10, irisin, secreted protein acidic risk in cysteine (SPARC), myostatin, oncostatin M and decorin might exert a direct inhibitory effect on cancer growth via inhibiting proliferation, promoting apoptosis, inducing cell-cycle arrest and inhibiting the epithermal transition to mesenchymal cells. The association of insulin resistance, hyperinsulinaemia and hyperlipidaemia with obesity can create a tumour-favourable environment; exercise-induced myokines can manipulate this environment by regulating adipose tissue and adipocytes. Exercise-induced myokines also have a critical role in increasing cytotoxicity and the infiltration of immune cells into the tumour.

Indexed as

AdenocarcinomaApoptosisCell Cycle CheckpointsCell ProliferationCytokinesDecorinEpithelial-Mesenchymal TransitionExerciseFibronectinsHumansHyperinsulinismHyperlipidemiasInsulin ResistanceInterleukin-10Interleukin-15Interleukin-6CytokinesDecorinFibronectinsFNDC5 protein, humanInterleukin-10Interleukin-15Interleukin-6MyostatinOncostatin MOsteonectin

Identifiers

PMID34158658
OpenAlexW3175266171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.