ArticleNature metabolism2021
Secretin activates brown fat and induces satiation.
Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function.American journal of physiology. Endocrinology and metabolism · 2022Trial
- Meal-Induced Proton Density Fat Fraction andNMR in biomedicine · 2026Article
- Impaired Renal Base Excretion in Secretin Receptor Knock-Out Mice During Prolonged Base-Loading.Acta physiologica (Oxford, England) · 2026Article
- Variants of Visceral Adipocytokine Genes in Obesity and Coronary Atherosclerosis: A Review.Current medicinal chemistry · 2026Review
- Brain cannabinoid CB1 receptor signaling modulates reward responses and inhibitory control in humans.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Dark seasons enhance brain and brown adipose tissue interactions related to mu-opioid receptor signaling.European journal of nuclear medicine and molecular imaging · 2025Article
- Anorexia nervosa is associated with higher brain mu-opioid receptor availability.Molecular psychiatry · 2025Article
- Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans.Nature metabolism · 2025Article
- Emerging debates and resolutions in brown adipose tissue research.Cell metabolism · 2025Review
- Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese rats.bioRxiv : the preprint server for biology · 2024Article
- Sympathetic Innervation of Interscapular Brown Adipose Tissue Is Not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats.Current issues in molecular biology · 2024Article
- Secretin: a hormone for HCOPflugers Archiv : European journal of physiology · 2024Review
- Physiological Appetite Regulation and Bariatric Surgery.Journal of clinical medicine · 2024Review
- Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice.Nature communications · 2024Article
- Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats.Frontiers in drug delivery · 2024Article
- Hormone-induced body-brain interaction and the impact on cognition.European journal of nuclear medicine and molecular imaging · 2024Article
- The intestine as an endocrine organ and the role of gut hormones in metabolic regulation.Nature reviews. Gastroenterology & hepatology · 2023Review
- Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts.Adipocyte · 2023Review
- Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity.Journal of personalized medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown adipose tissue (BAT) thermogenesis is activated by feeding. Recently, we revealed a secretin-mediated gut-BAT-brain axis, which stimulates satiation in mice, but the purpose of meal-induced BAT activation in humans has been unclear. In this placebo-controlled, randomized crossover study, we investigated the effects of intravenous secretin on BAT metabolism (measured with [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.