Evidence map›Paper›PMID 34158597›Full record

ArticleScientific reports2021

Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density.

Benedetta Bendinelli, Alessia Vignoli, Domenico Palli, Melania Assedi, Daniela Ambrogetti, Claudio Luchinat, Saverio Caini, Calogero Saieva, Paola Turano, Giovanna Masala

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benedetta BendinelliInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Alessia VignoliConsorzio Interuniversitario Risonanze Magnetiche Di Metallo Proteine (CIRMMP), 50019, Sesto Fiorentino, Italy.
Domenico PalliInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy. d.palli@ispro.toscana.it.
Melania AssediInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Daniela AmbrogettiInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Claudio LuchinatMagnetic Resonance Center (CERM), University of Florence, 50019, Sesto Fiorentino, Italy.
Saverio CainiInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Calogero SaievaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.
Paola TuranoMagnetic Resonance Center (CERM), University of Florence, 50019, Sesto Fiorentino, Italy.
Giovanna MasalaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammographic breast density (MBD) is a strong independent risk factor for breast cancer (BC). We designed a matched case-case study in the EPIC Florence cohort, to evaluate possible associations between the pre-diagnostic metabolomic profile and the risk of BC in high- versus low-MBD women who developed BC during the follow-up. A case-case design with 100 low-MBD (MBD ≤ 25%) and 100 high-MDB BC cases (MBD > 50%) was performed. Matching variables included age, year and type of mammographic examination.

Indexed as

Breast DensityMammographyMetabolomeAdultBreast NeoplasmsDiscriminant AnalysisFemaleHumansLeast-Squares AnalysisLipidsLipoproteinsMiddle AgedPrincipal Component AnalysisLipidsLipoproteins

Identifiers

PMID34158597
PMCPMC8219761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.