ArticleNature communications2021
Aryl radical-mediated N-heterocyclic carbene catalysis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 171 citations in OpenAlex.
- From reagents to feedstocks: reprogramming heteroatom-containing molecules in modern organic synthesis.Molecular diversity · 2026Review
- Asymmetric radical NHC organocatalysis-enabled highly enantioselective acylation of inert C(spScience advances · 2026Article
- Intramolecular PCET of α-Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials.Nature communications · 2025Article
- Photobiocatalytic Enantioselective Benzylic C(spJournal of the American Chemical Society · 2025Article
- NHC-Mediated Radical Acylation Catalyzed by Thiamine- and Flavin-Dependent Enzymes.Journal of the American Chemical Society · 2025Article
- Enantioselective acyl-trifluoromethylation of olefins by bulky thiazolium carbene catalysis.Nature communications · 2025Article
- Iodoarene Activation: Take a Leap Forward toward Green and Sustainable Transformations.Chemical reviews · 2025Review
- Article
- Light-Driven Enantioselective Carbene-Catalyzed Radical-Radical Coupling.Angewandte Chemie (International ed. in English) · 2023Article
- Recent advances in combining photo- and N-heterocyclic carbene catalysis.Chemical science · 2023Review
- Oxidative Cross Dehydrogenative Coupling ofJournal of the American Chemical Society · 2023Article
- Ketones from aldehydes via alkyl C(spNature communications · 2023Article
- On the Redox Properties of the Dimers of Thiazol-2-ylidenes That Are Relevant for Radical Catalysis.ACS organic & inorganic Au · 2023Article
- Photoinduced Acylations Via Azolium-Promoted Intermolecular Hydrogen Atom Transfer.Journal of the American Chemical Society · 2023Article
- Gauging Radical Stabilization with Carbenes.Angewandte Chemie (International ed. in English) · 2022Article
- Three-component carboacylation of alkenesChemical science · 2022Article
- Synthesis of Highly Congested Tertiary Alcohols via the [3,3] Radical Deconstruction of Breslow Intermediates.Organic letters · 2022Article
- Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones.Nature communications · 2022Article
- Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis.Nature communications · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been significant advancements in radical reactions using organocatalysts in modern organic synthesis. Recently, NHC-catalyzed radical reactions initiated by single electron transfer processes have been actively studied. However, the reported examples have been limited to catalysis mediated by alkyl radicals. In this article, the NHC organocatalysis mediated by aryl radicals has been achieved. The enolate form of the Breslow intermediate derived from an aldehyde and thiazolium-type NHC in the presence of a base undergoes single electron transfer to an aryl iodide, providing an aryl radical. The catalytically generated aryl radical could be exploited as an arylating reagent for radical relay-type arylacylation of styrenes and as a hydrogen atom abstraction reagent for α-amino C(sp
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.