ArticleNature communications2021
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson's Disease and in an α-Synuclein Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Klotho in aging and diseases: molecular features, expressions, and functional implications.Molecular and cellular biochemistry · 2026Review
- KLOTHO-VS heterozygosity, α-klotho protein levels and cognitive performance in Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Multimodal spatial gradients to explain regional susceptibility to fibrillar tau in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Associations of KLOTHO-VS heterozygosity and α-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers.Journal of Alzheimer's disease : JAD · 2025Article
- Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases.Molecular biomedicine · 2025Review
- The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer's Disease.Neurochemical research · 2025Review
- Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration.Frontiers in aging neuroscience · 2025Article
- Article
- The relationship between serum α-Klotho with all-cause and cause-specific mortality.British journal of clinical pharmacology · 2024Article
- Amyloid-β positivity is less prevalent in cognitively unimpairedJournal of Alzheimer's disease : JAD · 2024Article
- Review
- Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024Review
- KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Apolipoproteine andInternational journal of molecular sciences · 2024Article
- Knockout of the longevity gene Klotho perturbs aging and Alzheimer's disease-linked brain microRNAs and tRNA fragments.Communications biology · 2024Article
- Association between remnant cholesterol and anti-aging soluble α-klotho protein: New perspective on anti-aging from a NHANES study.Irish journal of medical science · 2024Article
- PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies.Genome medicine · 2024Article
- The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
Corrections and comments
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Authors and funding
8 authors at 20 institutions in 5 countries.
Julia NeitzelInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany. j.neitzel@erasmusmc.nl.ORCID 0000-0001-5739-466X
Nicolai FranzmeierInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.ORCID 0000-0001-9736-2283
Anna RubinskiInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.ORCID 0000-0002-0654-387X
Matthias BrendelDepartment of Nuclear Medicine, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.ORCID 0000-0002-9247-2843
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Rainer MalikInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Michael EwersInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany. Michael.Ewers@med.uni-muenchen.de.ORCID 0000-0001-5231-1714
Mayo Clinic in Florida · USWashington University in St. Louis · USBrigham and Women's Hospital · USUniversity of California, Irvine · USIndiana University Bloomington · USNew York University · USUC San Diego Health System · USUniversity of California, Los Angeles · USUniversity of Kentucky · USLAC+USC Medical Center · USNorthwestern University · USProvidence College · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Southern California · USBanner Sun Health Research Institute · USBaylor College of Medicine · USJohns Hopkins University · USUniversity of California, Davis · USUniversity of California, San Francisco · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1MCIHRNIA NIH HHS P30 AG066462NIA NIH HHS U01 AG024904
Abstract
Klotho-VS heterozygosity (KL-VS
Indexed as
AgedAlzheimer DiseaseAmyloid beta-PeptidesApolipoproteins EBrainFemaleGene ExpressionGlucuronidaseHeterozygoteHumansKlotho ProteinsMaleMemory DisordersMiddle AgedPolymorphism, Single NucleotidePositron-Emission TomographyAmyloid beta-PeptidesApolipoproteins EGlucuronidaseKlotho Proteinstau Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.