Evidence map›Paper›PMID 34158415›Full record

ArticleInternational journal of stem cells2021

PSC-MSC-Derived Exosomes Protect against Kidney Fibrosis

Limin Liu, Yao Wu, Pingan Wang, Min Shi, Juning Wang, Huaifen Ma, Dangze Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  13. Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Limin LiuDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Yao WuDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Pingan WangDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Min ShiDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Juning WangDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Huaifen MaDepartment of Basic Medicine, School of Medicine, Xi'an Peihua University, Xi'an, China.
Dangze SunDepartment of Thoracic Surgery, Xi'an Chest Hospital, Xi'an, China.
Xi'an Peihua University · CNXi'an Chest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesChronic kidney disease (CKD) has a major impact on the quality of life of patients, and renal fibrosis is a critical pathological change in the disease. It is very important to control the process of renal fibrosis to improve the quality of life of patients with CKD. The pathological mechanism of renal fibrosis is very complicated, and the current treatment strategy also has many flaws. METHODS AND

resultsTo explore a better treatment, we collected exosomes from pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSC) and verified their therapeutic effect on renal fibrosis through

conclusionsThese findings suggest the possibility of PSC-MSC-derived exosomes as a new, effective therapeutic tool for kidney fibrosis.

Indexed as

ExosomesRenal fibrosisSIRT6UUO

Identifiers

PMID34158415
PMCPMC8429948
OpenAlexW3174329592

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.