Evidence map›Paper›PMID 34158413›Full record

ArticleInternational journal of stem cells2021

Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model.

Xin Jin, Jiali Hou, Ke Zheng, Dan Wei, Ali Zhang, Siqi Wang, Hua Mei, Chuang Li, Lamei Cheng, Xuan Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Stem cell therapy in systemic sclerosis.Clinical rheumatology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Xin JinInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Jiali HouInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Ke ZhengInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Dan WeiInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Ali ZhangCentre for Cardiovascular Sciences, Queen's Medical Research Institute, School of Clinical Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
Siqi WangNational Engineering Research Center of Human Stem Cells, Changsha, China.
Hua MeiNational Engineering Research Center of Human Stem Cells, Changsha, China.
Chuang LiNational Engineering Research Center of Human Stem Cells, Changsha, China.
Lamei ChengInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Xuan SunInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, China.
Central South University · CNNational Engineering Research Center of Human Stem Cells · CNThe Queen's Medical Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSystemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory disease. In this study, preventive effect of single systemic human umbilical cord mesenchymal stem cells (UC-MSCs) transfusion on SSc was preliminarily explored. METHODS AND

resultsSSc mouse model was established by daily intradermal injection of Hypochlorite (HOCl). SSc mice were treated by single transfusion of UC-MSCs at 0.625×10

conclusionsUC-MSC can achieve a preventive effect in SSc mice by fibrosis attenuation and immunoregulation.

Indexed as

ImmunoregulationMesenchymal stem cellsRegulatory T cellSystemic scleroderma

Identifiers

PMID34158413
PMCPMC8429945
OpenAlexW3175230986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.