Evidence map›Paper›PMID 34158410›Full record

ArticleScience translational medicine2021

Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States.

Heather Kalish, Carleen Klumpp-Thomas, Sally Hunsberger, Holly Ann Baus, Michael P Fay, Nalyn Siripong, Jing Wang, Jennifer Hicks, Jennifer Mehalko, Jameson Travers and 43 more

Open access · hybridAbstract read
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
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  15. Canada's approach to SARS-CoV-2 sero-surveillance: Lessons learned for routine surveillance and future pandemics.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors at 9 institutions in 1 country.

Heather KalishTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-4848-2067
Carleen Klumpp-ThomasNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0002-6646-6132
Sally HunsbergerBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Holly Ann BausClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Michael P FayBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8643-9625
Nalyn SiripongClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-0157-0075
Jing WangClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jennifer HicksTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.
Jennifer MehalkoProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jameson TraversNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Matthew DrewProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0002-3954-6671
Kyle PaulyTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.
Jacquelyn SpathiesTrans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8259-9939
Tran NgoSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-4093-7004
Kenneth M AduseiSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-9539-1387
Maria KarkanitsaSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-3474-2371
Jennifer A CrokerCenter for Clinical and Translational Science, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-6292-4132
Yan LiJoint Program in Survey Methodology, Department of Epidemiology and Biostatistics, University of Maryland College Park, College Park, MD 20742, USA.ORCID 0000-0001-8241-7464
Barry I GraubardDivision of Cancer Epidemiology and Genetics, Biostatistics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-6787-1105
Lindsay CzajkowskiClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Olivia BelliveauLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Cheryl ChairezLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Kelly R SneadProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Peter FrankProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0001-8085-7845
Anandakumar ShunmugavelSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0001-8230-7361
Alison HanClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-7622-7696
Luca T GiurgeaClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8696-6927
Luz Angela RosasClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-8743-7189
Rachel BeanClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-1079-5498
Rani AthotaClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Adriana Cervantes-MedinaClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Monica GouzoulisClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Brittany HeffelfingerClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0001-6500-9012
Shannon ValentiClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-4856-5062
Rocco CaldararoClinical Research Directorate, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.
Michelle M KolbergDivision of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Andrew KellyNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Reid SimonNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0002-9629-3412
Saifullah ShafiqNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Vanessa WallProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0002-6972-239X
Susan ReedClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA.
Eric W FordCenter for Clinical and Translational Science, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-7885-0019
Ravi LokwaniSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA.
John-Paul DensonProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Simon MessingProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Sam G MichaelNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0002-1070-6563
William GilletteProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0002-8592-3642
Robert P KimberlyCenter for Clinical and Translational Science, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-5330-3086
Steven E ReisClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0002-5073-442X
Dominic EspositoProtein Expression Laboratory, NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0002-9987-1687
Matthew J MemoliClinical Studies Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20894, USA. memolim@nih.gov kaitlyn.sadtler@nih.gov.ORCID 0000-0001-6393-5178
Kaitlyn SadtlerSection on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20894, USA. memolim@nih.gov kaitlyn.sadtler@nih.gov.ORCID 0000-0003-2587-8330
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USProtein Express (United States) · USNational Institute of Biomedical Imaging and Bioengineering · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USFrederick National Laboratory for Cancer Research · USLeidos (United States) · USUniversity of Maryland, College Park · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI PENDLETON, RICHARD · 2019 to 2025
$3932.6M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Research Services Section (RSS)ZICTR000242 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI WILSON, KELLI · 2015 to 2025
$64.9M
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Micro Analytical ImmunochemistryZICEB000076 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI KALISH, HEATHER · 2011 to 2025
$6.3M
ImmunoengineeringZIAEB000093 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SADTLER, KAITLYN · 2020 to 2025
$5.5M
Coronavirus Pathogenesis and Broadly Protective Vaccine DevelopmentZIAAI001268 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MEMOLI, MATTHEW · 2020 to 2025
$4.8M
CCR NIH HHS HHSN261200800001CNCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR003096NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates in the United States and elsewhere. To address this, we analyzed seropositivity in 9089 adults in the United States who had not been diagnosed previously with COVID-19. Individuals with characteristics that reflected the U.S. population (

Indexed as

COVID-19PandemicsAdultAntibodies, ViralFemaleHumansSARS-CoV-2Spike Glycoprotein, CoronavirusUnited StatesAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID34158410
PMCPMC8432952
OpenAlexW3177069673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.