Evidence map›Paper›PMID 34158363›Full record

ArticleDiabetes care2021

Weight Loss by Low-Calorie Diet Versus Gastric Bypass Surgery in People With Diabetes Results in Divergent Brain Activation Patterns: A Functional MRI Study.

Victoria Salem, Lysia Demetriou, Preeshila Behary, Kleopatra Alexiadou, Samantha Scholtz, George Tharakan, Alexander D Miras, Sanjay Purkayastha, Ahmed R Ahmed, Stephen R Bloom and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Victoria SalemDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.ORCID 0000-0001-6463-7471
Lysia DemetriouInvicro London, Hammersmith Hospital, London, U.K.
Preeshila BeharyDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.
Kleopatra AlexiadouDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.
Samantha ScholtzWest London Mental Health National Health Service Trust, London, U.K.
George TharakanDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.
Alexander D MirasDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.ORCID 0000-0003-3830-3173
Sanjay PurkayasthaDepartment of Surgery and Cancer, Imperial College Healthcare National Health Service Trust, London, U.K.
Ahmed R AhmedDepartment of Surgery and Cancer, Imperial College Healthcare National Health Service Trust, London, U.K.
Stephen R BloomDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.
Matthew B WallDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.
Waljit S DhilloDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K.ORCID 0000-0001-5950-4316
Tricia M-M TanDepartment of Digestion, Metabolism and Reproduction, Imperial College London, London, U.K. t.tan@imperial.ac.uk.ORCID 0000-0001-5873-3432
Imperial College London · GBHammersmith Hospital · GBImperial College Healthcare NHS Trust · GBWest London Mental Health NHS Trust · GB

Funding

Biotechnology and Biological Sciences Research CouncilDepartment of Health RP-2014-05-001Medical Research Council MR/K02115X/1
6 · The paper itself

Abstract

objectiveWeight loss achieved with very-low-calorie diets (VLCDs) can produce remission of type 2 diabetes (T2D), but weight regain very often occurs with reintroduction of higher calorie intakes. In contrast, bariatric surgery produces clinically significant and durable weight loss, with diabetes remission that translates into reductions in mortality. We hypothesized that in patients living with obesity and prediabetes/T2D, longitudinal changes in brain activity in response to food cues as measured using functional MRI would explain this difference. RESEARCH DESIGN AND

methodsSixteen participants underwent gastric bypass surgery, and 19 matched participants undertook a VLCD (meal replacement) for 4 weeks. Brain responses to food cues and resting-state functional connectivity were assessed with functional MRI pre- and postintervention and compared across groups.

resultsWe show that Roux-en-Y gastric bypass surgery (RYGB) results in three divergent brain responses compared with VLCD-induced weight loss:

conclusionsTaken together, these findings point to divergent brain responses to different methods of weight loss in patients with diabetes, which may explain weight regain after a short-term VLCD in contrast to enduring weight loss after RYGB.

Indexed as

Diabetes Mellitus, Type 2Gastric BypassObesity, MorbidBrainCaloric RestrictionHumansMagnetic Resonance ImagingWeight Loss

Identifiers

PMID34158363
PMCPMC8385466
OpenAlexW3174672248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.