ArticleRadiation oncology (London, England)2021
Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy.
Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hippocampal Atrophy Following Therapeutic Irradiation of Intracranial and Nasopharyngeal Tumors.Cureus · 2025Review
- A Comparative Study of Five Target Volume Definitions for Radiotherapy in Glioblastoma Multiforme.Medicina (Kaunas, Lithuania) · 2025Article
- Assessment of Radiation Dosage to the Hippocampi during Treatment of Multiple Brain Metastases Using Gamma Knife Therapy.Medicina (Kaunas, Lithuania) · 2024Article
- Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review.Frontiers in oncology · 2024Review
- Recurrence analysis of glioblastoma cases based on distance and dose information.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- A Comprehensive Dosimetric and Plan Quality Evaluation of Non-coplanar VMAT With Flattening Filter-free Versus Flattened Beams for Hippocampal-Avoidance Whole-Brain Radiotherapy: A Multi-Platform Study on Elekta Infinity and UIH uRT-Linac Systems.Technology in cancer research & treatmentArticle
- Structural connectome-based predictive modeling of cognitive deficits in treated glioma patients.Neuro-oncology advancesArticle
- Precision Radiotherapy for Gliomas: Implementing Novel Imaging Biomarkers to Improve Outcomes With Patient-Specific Therapy.Cancer journal (Sudbury, Mass.)Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundThe hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.
methodsAll patients were treated for glioblastoma with surgery, concomitant radiotherapy and temozolomide, and adjuvant temozolomide. Hippocampi were retrospectively delineated on three MRIs, performed at baseline, at the time of relapse, and on the last MRI available at the end of follow-up. A total of 98, 96, and 82 hippocampi were measured in the 49 patients included in the study, respectively. The patients were stratified into three subgroups according to the dose delivered to 40% of the hippocampus. In the group 1 (n = 6), the hippocampal D
resultsRegardless of the time of measurement, homolateral hippocampal volumes were significantly lower than those contralateral to the tumor. Regardless of the side, the volumes at the last MRI were significantly lower than those measured at baseline. There was a significant correlation among the decrease in hippocampal volume regardless of its side, and D
conclusionsThere was a significant relationship between the radiotherapy dose and decrease in hippocampal volume. However, at the lowest doses, the hippocampi seem to exhibit an adaptive increase in their volume, which could indicate a plasticity effect. Consequently, shielding at least one hippocampus by delivering the lowest possible dose is recommended so that cognitive function can be preserved. Trial registration Retrospectively registered.
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